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dc.contributor.authorTrampush, Joey W.
dc.contributor.authorYang, M.L.Z.
dc.contributor.authorYu, Jin
dc.contributor.authorKnowles, Emma
dc.contributor.authorDavies, Gail
dc.contributor.authorLiewald, David C.M.
dc.contributor.authorStarr, John M.
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorMelle, Ingrid
dc.contributor.authorSundet, Kjetil Søren
dc.contributor.authorChristoforou, Andrea
dc.contributor.authorReinvang, Ivar
dc.contributor.authorDeRosse, Pamela
dc.contributor.authorLundervold, Astri
dc.contributor.authorSteen, Vidar Martin
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorWidén, Elisabeth
dc.contributor.authorPalotie, Aarno
dc.contributor.authorEriksson, Johan Gunnar
dc.contributor.authorGiegling, Ina
dc.contributor.authorKonte, Bettina
dc.contributor.authorRoussos, Panos
dc.contributor.authorGiakoumaki, Stella
dc.contributor.authorBurdick, Katherine E.
dc.contributor.authorPayton, Antony
dc.contributor.authorOllier, William E.R.
dc.contributor.authorHoran, Michael Arthur
dc.contributor.authorChiba-Falek, Ornit
dc.contributor.authorAttix, Deborah K.
dc.contributor.authorNeed, Anna C.
dc.contributor.authorCirulli, Elizabeth Trilby
dc.contributor.authorVoineskos, Aristotle N.
dc.contributor.authorStefanis, Nikos C.
dc.contributor.authorAvramopoulos, Dimitrios A.
dc.contributor.authorHatzimanolis, Alex
dc.contributor.authorArking, Dan E.
dc.contributor.authorSmyrnis, Nikolaos
dc.contributor.authorBilder, Robert Martin
dc.contributor.authorFreimer, Nelson A.
dc.contributor.authorCannon, Tyrone D.
dc.contributor.authorLondon, Edyth
dc.contributor.authorPoldrack, Russell Alan
dc.contributor.authorSabb, Fred W.
dc.contributor.authorCongdon, Eliza L.
dc.contributor.authorConley, Emily Drabant
dc.contributor.authorScult, Matthew A.
dc.contributor.authorDickinson, Dwight
dc.contributor.authorStraub, Richard E.
dc.contributor.authorDonohoe, Gary J.
dc.contributor.authorMorris, Derek W.
dc.contributor.authorCorvin, Aiden
dc.contributor.authorGill, Michael
dc.contributor.authorHariri, Ahmad
dc.contributor.authorWeinberger, Daniel R.
dc.contributor.authorPendleton, Neil
dc.contributor.authorBitsios, Panos
dc.contributor.authorRujescu, Dan
dc.contributor.authorLahti, Jari
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorKeller, Matthew C.
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorDeary, Ian John
dc.contributor.authorGlahn, David C.
dc.contributor.authorMalhotra, Anil K.
dc.contributor.authorLencz, Todd
dc.PublishedTrampush JW, Yang, Yu, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, et al. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium. Molecular Psychiatry. 2017;22(3):336-345eng
dc.description.abstractThe complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10^−8). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.en_US
dc.rightsAttribution CC BYeng
dc.titleGWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortiumeng
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Authorseng
dc.source.journalMolecular Psychiatry

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