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dc.contributor.authorEide, Marta
dc.contributor.authorRydbeck, Halfdan
dc.contributor.authorTørresen, Ole K.
dc.contributor.authorLille-Langøy, Roger
dc.contributor.authorPuntervoll, Pål
dc.contributor.authorGoldstone, Jared V.
dc.contributor.authorJakobsen, Kjetill Sigurd
dc.contributor.authorStegeman, John
dc.contributor.authorGoksøyr, Anders
dc.contributor.authorKarlsen, Odd Andre
dc.PublishedEide M, Rydbeck H, Tørresen OK, Lille-Langøy R, Puntervoll P, Goldstone JV, Jakobsen KS, Stegeman J, Goksøyr A, Karlsen OA. Independent losses of a xenobiotic receptor across teleost evolution. Scientific Reports. 2018;8:10404eng
dc.description.abstractSensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fish genomes enable us to trace the evolution of defense genes in the largest and most diverse group of vertebrates. Through genomic searches and in-depth analysis of gene loci in 76 teleost genomes, we show here that the xenosensor pregnane X receptor (Pxr, Nr1i2) is absent in more than half of these species. Notably, out of the 27 genome assemblies that belong to the Gadiformes order, the pxr gene was only retained in the Merluccidae family (hakes) and Pelagic cod (Melanonus zugmayeri). As an important receptor for a wide range of drugs and environmental pollutants, vertebrate PXR regulate the transcription of a number of genes involved in the biotransformation of xenobiotics, including cytochrome P450 enzymes (CYP). In the absence of Pxr, we suggest that the aryl hydrocarbon receptor (Ahr) have evolved an extended regulatory role by governing the expression of certain Pxr target genes, such as cyp3a, in Atlantic cod (Gadus morhua). However, as several independent losses of pxr have occurred during teleost evolution, other lineages and species may have adapted alternative compensating mechanisms for controlling crucial cellular defense mechanisms.en_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution CC BYeng
dc.titleIndependent losses of a xenobiotic receptor across teleost evolutionen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)en_US
dc.source.journalScientific Reports

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