Browsing Master theses by Subject "759929"
Now showing items 1-20 of 31
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A study of autophagy gene expression in autoimmune Addison's disease
(Master thesis, 2022-06-01) -
Advanced CRISPR-Cas9 techniques for modulation of non-coding disease-associated genetic variants
(Master thesis, 2023-06-02)The search for genetic explanations of individual susceptibility to complex polygenic diseases has greatly intensified in recent years, with GWAS studies having successfully linked several hundred thousand genomic loci to ... -
Characterization of the CEL-MODY mouse – A new disease model for chronic pancreatitis
(Master thesis, 2020-06-19) -
Characterization of the pregnane X receptor (PXR) from European hake (Merluccius merluccius): cloning, ligand activation, and bioinformatical analyses
(Master thesis, 2022-09-08)As a response to adverse environmental conditions, organisms have throughout evolution generated a collection of gene families and pathways providing protection and repair of damage caused by physical, chemical, and ... -
Early studies on a novel phosphoinositide 3-kinase p110β isoform, and its localisation
(Master thesis, 2020-12-23)Phosphoionositide 3-kinase (PI3K) is a family of enzymes that are part of the PI3K signalling pathway, which is one of the most often altered pathways in human cancer. The PI3K family is divided into three classes, where ... -
Fat-depot specific differences in adipose tissue inflammation in the setting of obesity and insulin resistance
(Master thesis, 2020-07-01) -
Functional analysis of BRCA1 variants of uncertain significance (VUS)
(Master thesis, 2022-06-01) -
Functional and molecular characterisation of a unique double homozygous variant causing ABCA4-related retinopathy
(Master thesis, 2023-06-02) -
Functional assessment of 3'UTR regulatory elements using the zebrafish (Danio rerio) model system - towards modulating protein levels in Atlantic salmon (Salmo salar) for more sustainable aquaculture
(Master thesis, 2021-11-22)Post-transcriptional regulation is a complex process that encompasses a myriad of different structures and mechanisms. There are several indications that regulatory elements in the 3'UTR play an important role in the ... -
Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
(Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
Gene-editing of the monogenic diabetes associated gene hnf1ba to model multisystemic MODY5 disease mechanisms in zebrafish (DR)
(Master thesis, 2021-12-03)Maturity-Onset Diabetes of the Young (MODY) is a rare form of monogenic diabetes, characterized by autosomal dominant inheritance, non-obesity, and early-onset diabetes due to reduced pancreatic beta-cell secretion. Precision ... -
Impact of cysteine 106 oxidation on function and localisation of the Parkinson’s disease-related protein DJ-1
(Master thesis, 2019-06-22) -
Interaksjoner mellom marine næringsstoffer og dioksiner hos mus med human AhR
(Master thesis, 2021-11-22)Dioksiner og dioksinlignende PCB er en gruppe kjemiske forbindelser dannet via industrielle prosesser, som grunnet høy persistens vil akkumulere i fettvev hos mennesker og dyr. Fet fisk regnes som den største kilden til ... -
Investigating endosomal pathway regulation of Liver Kinase B1 in Drosophila Melanogaster
(Master thesis, 2022-11-21)Within a cell, efficient intracellular trafficking is essential for various functions, including cellular polarity, cell signalling, and maintenance of homeostasis by regulation of cellular energy. Liver kinase B1 (LKB1), ... -
Investigating hydroxylation of the acetyltransferase NAA10 as a potential regulation mechanism
(Master thesis, 2019-12-14) -
Investigations of the CEL VNTR by cellular experiments and in silico analyses
(Master thesis, 2023-06-02)Carboxyl ester lipase (CEL) is a digestive enzyme which is secreted by acinar cells in the pancreas and released into the intestines. In addition to the globular domain responsible for lipase activity, CEL contains a ... -
Mapping the amino acid composition of the peripheral membrane binding interface of PH domains
(Master thesis, 2021-11-24)Biological membranes are important in the organization of cells, and the main components of membranes are different kinds of lipids. Peripheral proteins are soluble and interact transiently and bind reversibly to lipids ... -
Regulation of polypyrimidine tract binding protein 1 by class 1A phosphoinositide 3-kinase p110-beta activity in cancer cells
(Master thesis, 2022-11-21)Polypyrimidine tract binding protein 1 (PTB) is an extensively expressed RNA binding protein that regulates alternate splicing of exons in the nucleus. PTB is also localized in a nuclear body called perinucleolar compartment ... -
Role of PIP binding motifs on the nucleolar localization and function of ErbB3 binding protein 1
(Master thesis, 2020-07-01)Sub-cellular localization is key to the specific function of proteins. Proteins can be recruited to different cell compartments via their interaction with the signaling lipids, polyphosphoinositides (PPIn). While their ...