Show simple item record

dc.contributor.authorKjærner-Semb, Erik Nordtorp
dc.contributor.authorAyllon, Fernando
dc.contributor.authorKleppe, Lene
dc.contributor.authorSørhus, Elin
dc.contributor.authorSkaftnesmo, Kai Ove
dc.contributor.authorFurmanek, Tomasz
dc.contributor.authorSegafredo, Frida Thyri
dc.contributor.authorThorsen, Anders
dc.contributor.authorFjelldal, Per Gunnar
dc.contributor.authorHansen, Tom Johnny
dc.contributor.authorTaranger, Geir Lasse
dc.contributor.authorAndersson, Eva
dc.contributor.authorSchulz, Rüdiger W.
dc.contributor.authorWargelius, Anna
dc.contributor.authorEdvardsen, Rolf
dc.PublishedKjærner-Semb E, Ayllon F, Kleppe L, Sørhus E, Skaftnesmo KO, Furmanek TM, Segafredo FT, Thorsen A, Fjelldal PG, Hansen TJ, Taranger GL, Andersson E, Schulz RW, Wargelius A, Edvardsen R. Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis. Scientific Reports. 2018;8:1912eng
dc.description.abstractVgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 and the associated Hippo pathway has been linked to reduced proliferation activity in different tissues. Analysis of gene expression reveals for the first time that vgll3 and several members of the Hippo pathway were down-regulated in salmon testis during onset of puberty and remained repressed in maturing testis. In the gonads, we found expression in Sertoli and granulosa cells in males and females, respectively. We hypothesize that vgll3 negatively regulates Sertoli cell proliferation in testis and therefore acts as an inhibitor of pubertal testis growth. Gonadal expression of vgll3 is located to somatic cells that are in direct contact with germ cells in both sexes, however our results indicate sex-biased regulation of vgll3 during puberty.en_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution CC BYeng
dc.titleVgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)en_US
dc.source.journalScientific Reports
dc.relation.projectNorges forskningsråd: 226221
dc.relation.projectNorges forskningsråd: 221648
dc.relation.projectNorges forskningsråd: 254783

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY