Vis enkel innførsel

dc.contributor.authorPettersson, Mats E.
dc.contributor.authorRochus, Christina M.
dc.contributor.authorHan, Fan
dc.contributor.authorChen, Junfeng
dc.contributor.authorHill, Jason
dc.contributor.authorWallerman, Ola
dc.contributor.authorFan, Guangyi
dc.contributor.authorHong, Xiaoning
dc.contributor.authorXu, Qiwu
dc.contributor.authorZhang, He
dc.contributor.authorLiu, Shanshan
dc.contributor.authorLiu, Xin
dc.contributor.authorHaggerty, Leanne
dc.contributor.authorHunt, Toby
dc.contributor.authorMartin, Fergal J.
dc.contributor.authorFlicek, Paul
dc.contributor.authorBunikis, Ignas
dc.contributor.authorFolkvord, Arild
dc.contributor.authorAndersson, Leif
dc.PublishedPettersson ME, Rochus, Han, Chen, Hill J, Wallerman, Fan G, Hong, Xu Q, Zhang H, Liu, Liu X, Haggerty, Hunt, Martin, Flicek P, Bunikis, Folkvord A, Andersson L. A chromosome-level assembly of the Atlantic herring genome-detection of a supergene and other signals of selection. Genome Research. 2019;29:1919-1928eng
dc.description.abstractThe Atlantic herring is a model species for exploring the genetic basis for ecological adaptation, due to its huge population size and extremely low genetic differentiation at selectively neutral loci. However, such studies have so far been hampered because of a highly fragmented genome assembly. Here, we deliver a chromosome-level genome assembly based on a hybrid approach combining a de novo Pacific Biosciences (PacBio) assembly with Hi-C-supported scaffolding. The assembly comprises 26 autosomes with sizes ranging from 12.4 to 33.1 Mb and a total size, in chromosomes, of 726 Mb, which has been corroborated by a high-resolution linkage map. A comparison between the herring genome assembly with other high-quality assemblies from bony fishes revealed few inter-chromosomal but frequent intra-chromosomal rearrangements. The improved assembly facilitates analysis of previously intractable large-scale structural variation, allowing, for example, the detection of a 7.8-Mb inversion on Chromosome 12 underlying ecological adaptation. This supergene shows strong genetic differentiation between populations. The chromosome-based assembly also markedly improves the interpretation of previously detected signals of selection, allowing us to reveal hundreds of independent loci associated with ecological adaptation.en_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.titleA chromosome-level assembly of the Atlantic herring genome-detection of a supergene and other signals of selectionen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.source.journalGenome Research

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial CC BY-NC
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial CC BY-NC