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dc.contributor.authorDauwan, Meenakshi
dc.contributor.authorBegemann, Marieke J.H.
dc.contributor.authorSlot, Margot I.E.
dc.contributor.authorLee, Edwin H.M.
dc.contributor.authorScheltens, Philip
dc.contributor.authorSommer, Iris Else Clara
dc.date.accessioned2020-08-07T12:33:31Z
dc.date.available2020-08-07T12:33:31Z
dc.date.issued2019
dc.PublishedDauwan M, Begemann, Slot, Lee, Scheltens P, Sommer IEC. Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials. Journal of Neurology. 2019eng
dc.identifier.issn1432-1459
dc.identifier.issn0340-5354
dc.identifier.urihttps://hdl.handle.net/1956/23568
dc.description.abstractWe performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer’s disease, Huntington’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia and unipolar depression. 122 studies ( = k) (n = 7231) were included. Exercise was superior to treatment as usual in improving QoL (k = 64, n = 4334, ES = 0.40, p < 0.0001), depressive symptoms (k = 60, n = 2909, ES = 0.78, p < 0.0001), the cognitive domains attention and working memory (k = 21, n = 1313, ES = 0.24, p < 0.009), executive functioning (k = 14, n = 977, ES = 0.15, p = 0.013), memory (k = 12, n = 994, ES = 0.12, p = 0.038) and psychomotor speed (k = 16, n = 896, ES = 0.23, p = 0.003). Meta-regression showed a dose–response effect for exercise time (min/week) on depressive symptoms (β = 0.007, p = 0.012). 69% of the studies that reported on safety, found no complications. Exercise is an efficacious and safe add-on therapeutic intervention showing a medium-sized effect on QoL and a large effect on mood in patients with chronic brain disorders, with a positive dose–response correlation. Exercise also improved several cognitive domains with small but significant effects.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titlePhysical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trialseng
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-02-04T09:22:26Z
dc.description.versionpublishedVersion
dc.rights.holderCopyright 2019 The Author(s)eng
dc.identifier.doihttps://doi.org/10.1007/s00415-019-09493-9
dc.identifier.cristin1740801
dc.source.journalJournal of Neurology


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