Blar i Sars International Centre for Marine Molecular Biology på forfatter "Gahan, James Michael"
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A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian
Chrysostomou, Eleni; Flici, Hakima; Gornik, Sebastian G.; Salinas-Saavedra, Miguel; Gahan, James Michael; McMahon, Emma T.; Thompson, Kerry; Hanley, Shirley; Kilcoyne, Michelle; Schnitzler, Christine E.; Gonzalez, Paul; Baxevanis, Andreas D.; Frank, Uri (Journal article; Peer reviewed, 2022)Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their ... -
Cnidofest 2022: hot topics in cnidarian research
Gahan, James Michael; Cartwright, Paulyn; Nicotra, Matthew L.; Schnitzler, Christine E.; Steinmetz, Patrick; Juliano, Celina E. (Journal article; Peer reviewed, 2023-08-24)The second annual Cnidarian Model Systems Meeting, aka “Cnidofest”, took place in Davis, California from 7 to 10th of September, 2022. The meeting brought together scientists using cnidarians to study molecular and cellular ... -
A developmental role for the chromatin-regulating CoREST complex in the cnidarian Nematostella vectensis
Gahan, James Michael; Leclère, Lucas; Hernandez-Valladares, Maria; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)Background Chromatin-modifying proteins are key players in the regulation of development and cell differentiation in animals. Most chromatin modifiers, however, predate the evolution of animal multicellularity, and how ... -
Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ... -
Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis
Tourniere, Oceane Barbara; Gahan, James Michael; Busengdal, Henriette; Bartsch, Natascha; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other cell types are not well understood. We use here the sea anemone Nematostella vectensis as a model ...