• norsk
    • English
  • norsk 
    • norsk
    • English
  • Logg inn
Vis innførsel 
  •   Hjem
  • Faculty of Mathematics and Natural Sciences
  • Department of Biological Sciences
  • Department of Biological Sciences
  • Vis innførsel
  •   Hjem
  • Faculty of Mathematics and Natural Sciences
  • Department of Biological Sciences
  • Department of Biological Sciences
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation

Albers, Sonja-Verena; Birkeland, Nils-Kåre; Driessen, Arnold J. M.; Gertig, Susanne; Haferkamp, Patrick; Klenk, Hans-Peter; Kouril, Theresa; Manica, Andrea; Pham, Trong K.; Ruoff, Peter; Schleper, Christa Maria; Schomburg, Dietmar; Sharkey, Kieran J.; Siebers, Bettina; Sierocinski, Pawel; Steuer, Ralf; van der Oost, John; Westerhoff, Hans V.; Wieloch, Patricia; Wright, Philip C.; Zaparty, Melanie
Peer reviewed, Journal article
Accepted version
Thumbnail
Åpne
Albers_etal_2009.pdf (350.0Kb)
Permanent lenke
https://hdl.handle.net/1956/6936
Utgivelsesdato
2009
Metadata
Vis full innførsel
Samlinger
  • Department of Biological Sciences [1826]
Originalversjon
https://doi.org/10.1042/bst0370058
Sammendrag
SulfoSYS (Sulfolobus Systems Biology) focuses on the study of the CCM (central carbohydrate metabolism) of Sulfolobus solfataricus and its regulation under temperature variation at the systems level. In Archaea, carbohydrates are metabolized by modifications of the classical pathways known from Bacteria or Eukarya, e.g. the unusual branched ED (Entner–Doudoroff) pathway, which is utilized for glucose degradation in S. solfataricus. This archaeal model organism of choice is a thermoacidophilic crenarchaeon that optimally grows at 80◦C (60–92◦C) and pH 2–4. In general, life at high temperature requires very efficient adaptation to temperature changes, which is most difficult to deal with for organisms, and it is unclear how biological networks can withstand and respond to such changes. This integrative project combines genomic, transcriptomic, proteomic and metabolomic, as well as kinetic and biochemical information. The final goal of SulfoSYS is the construction of a silicon cell model for this part of the living cell that will enable computation of the CCM network. In the present paper, we report on one of the first archaeal systems biology projects.
Utgiver
Portland Press
Tidsskrift
Biochemical Society Transactions
Opphavsrett
Copyright The Authors Journal compilation. Copyright 2009 Biochemical Society. All rights reserved.

Kontakt oss | Gi tilbakemelding

Personvernerklæring
DSpace software copyright © 2002-2019  DuraSpace

Levert av  Unit
 

 

Bla i

Hele arkivetDelarkiv og samlingerUtgivelsesdatoForfattereTitlerEmneordDokumenttyperTidsskrifterDenne samlingenUtgivelsesdatoForfattereTitlerEmneordDokumenttyperTidsskrifter

Min side

Logg inn

Statistikk

Besøksstatistikk

Kontakt oss | Gi tilbakemelding

Personvernerklæring
DSpace software copyright © 2002-2019  DuraSpace

Levert av  Unit