Browsing Faculty of Science and Technology by Journals "Tetrahedron"

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    • Phenylethylene glycol-derived LpxC inhibitors with diverse Zn2+-binding groups 

      Galster, Magdalena; Loeppenberg, Marius; Galla, Fabian; Börgel, Frederik; Agoglitta, Oriana; Kirchmair, Johannes; Holl, Ralph (Peer reviewed; Journal article, 2019)
      The Zn2+-dependent bacterial deacetylase LpxC is a promising target for the development of novel antibiotics. Most of the known LpxC inhibitors carry a hydroxamate moiety as Zn2+-binding group. However, hydroxamic acids ...

    • Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism 

      Baumann, Markus; Nome, Lina Marie; Zachariassen, Zack Georg; Karlshøj, Stepfanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik (Peer reviewed; Journal article, 2017-07)
      We here report the preparation of a new 2,6,8-trisubstituted bicyclic tripeptidomimetic scaffold through TFA-mediated cyclization of a linear precursor containing three side chains. The introduction of a triphenylmethyl-protected ...