Blar i Department of Biological Sciences på emneord "759929"
Viser treff 21-40 av 61
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Functional assessment of 3'UTR regulatory elements using the zebrafish (Danio rerio) model system - towards modulating protein levels in Atlantic salmon (Salmo salar) for more sustainable aquaculture
(Master thesis, 2021-11-22)Post-transcriptional regulation is a complex process that encompasses a myriad of different structures and mechanisms. There are several indications that regulatory elements in the 3'UTR play an important role in the ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization. -
Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
(Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(Master thesis, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ... -
Functional dissection of a genetic locus for visceral fat mass (11q23.3)
(Master thesis, 2021-06-01) -
Gene-editing of the monogenic diabetes associated gene hnf1ba to model multisystemic MODY5 disease mechanisms in zebrafish (DR)
(Master thesis, 2021-12-03)Maturity-Onset Diabetes of the Young (MODY) is a rare form of monogenic diabetes, characterized by autosomal dominant inheritance, non-obesity, and early-onset diabetes due to reduced pancreatic beta-cell secretion. Precision ... -
Identification of Epigenetic Modifications Following Treatment with Olanzapine
(Master thesis, 2018-12-19)No chronic disease burdens the world more than psychiatric disorders (Collins et al., 2011), with an estimated 40% of the population in 30 European countries affected in any given year (Insel et al., 2012). Current medical ... -
Impact of cysteine 106 oxidation on function and localisation of the Parkinson’s disease-related protein DJ-1
(Master thesis, 2019-06-22) -
In-vitro characterization of pancreatic functional units from Cel-MODY mice
(Master thesis, 2021-06-01)The digestive enzyme carboxyl-ester lipase (CEL) is secreted by pancreatic acinar cells into the duodenum where it hydrolyzes dietary fat, cholesteryl esters, and fat-soluble vitamins. To date, two single-base mutations ... -
Interactions between marine nutrients and 2, 3, 7, 8 – Tetrachlorodibenzo-p-dioxin toxicity on reproduction of male wistar han rats
(Master thesis, 2020-12-23)Dioxins and dioxin-like polychlorinated biphenyls (dl-PCBs) are chemical congeners formed as by-products from incomplete thermic reactions, found in the environment because of improper disposal from industrial processes ... -
Interaksjoner mellom marine næringsstoffer og dioksiner hos mus med human AhR
(Master thesis, 2021-11-22)Dioksiner og dioksinlignende PCB er en gruppe kjemiske forbindelser dannet via industrielle prosesser, som grunnet høy persistens vil akkumulere i fettvev hos mennesker og dyr. Fet fisk regnes som den største kilden til ... -
Investigating endosomal pathway regulation of Liver Kinase B1 in Drosophila Melanogaster
(Master thesis, 2022-11-21)Within a cell, efficient intracellular trafficking is essential for various functions, including cellular polarity, cell signalling, and maintenance of homeostasis by regulation of cellular energy. Liver kinase B1 (LKB1), ... -
Investigating hydroxylation of the acetyltransferase NAA10 as a potential regulation mechanism
(Master thesis, 2019-12-14) -
Investigating the Versatility of a Flavin-containing Monooxygenase Engineered Towards Trimethylamine Conversion in Fish Protein Hydrolysate
(Master thesis, 2023-11-20)Byproducts from the seafood industry are rich in nutrients, such as peptides, which might be utilized to a greater extent in the food market. Peptides can be extracted from fish byproducts by enzymatic hydrolysis, but the ... -
Investigations of the CEL VNTR by cellular experiments and in silico analyses
(Master thesis, 2023-06-02)Carboxyl ester lipase (CEL) is a digestive enzyme which is secreted by acinar cells in the pancreas and released into the intestines. In addition to the globular domain responsible for lipase activity, CEL contains a ... -
Mapping the amino acid composition of the peripheral membrane binding interface of PH domains
(Master thesis, 2021-11-24)Biological membranes are important in the organization of cells, and the main components of membranes are different kinds of lipids. Peripheral proteins are soluble and interact transiently and bind reversibly to lipids ... -
Modelling and expression of the extracellular domain of the human guanylyl cyclase C receptor
(Master thesis, 2011-09-14)The human guanylyl cyclase C receptor is the target for the heat-stable entero- toxin (STa) from enterotoxigenic Escherichia coli, which is responsible for more than 200 million episodes of diarrhea and 300,000 deaths per ...