Browsing Department of Biological Sciences by Author "Høivik, Erling Andre"
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Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
Mazloumi Gavgani, Fatemeh; Arnesen, Victoria Smith; Jacobsen, Rhian Gaenor; Krakstad, Camilla; Høivik, Erling Andre; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2018-12-07)The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ... -
Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation
Karlsson, Thomas; Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Pollock, Pamela M.; Salvesen, Helga; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2017-12-16)PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β ...