• Breastfeeding patterns and its determinants among mothers living with Human Immuno-deficiency Virus -1 in four African countries participating in the ANRS 12174 trial 

      Some, Nagaonle Eric; Engebretsen, Ingunn Marie S.; Nagot, Nicolas; Meda, Nicolas; Lombard, Carl; Vallo, Roselyne; Peries, Marianne; Kankasa, Chipepo; Tumwine, James K; Hofmeyr, G. Justus; Singata, Mandisa; Harper, Kim; Van De Perre, Philippe; Tylleskär, Thorkild (Peer reviewed; Journal article, 2017-05-02)
      Background:  HIV-1 transmission rates have been reduced over the last decade, an estimated 2 million new infections per year arise, including 220,000 paediatric cases. The main post-natal HIV exposure is through breastfeeding, ...
    • Changes in body mass index and hemoglobin concentration in breastfeeding women living with HIV with a CD4 count over 350: Results from 4 African countries (The ANRS 12174 trial) 

      Somé, Eric; Engebretsen, Ingunn Marie S.; Nagot, Nicolas; Meda, Nicolas Y; Vallo, Roselyne; Kankasa, Chipepo; Tumwine, James K; Singata, Mandisa; Hofmeyr, Justus G; Van De Perre, Philippe; Tylleskär, Thorkild; Marechal, Valerie; Neveu, Dorine; Foulongne, Vincent; Segondy, Michel; Schaub, Roxanne; Blanche, Stephane; Treluyer, Jean-Marc; Hirt, Deborah; Karamagi, Charles; Musoke, Philippa; Ndeezi, Grace; Mugaba, Proscovia M; Kwagala, Mary; Murungi, Joan; Muweesi, Hawa Nabuuma; Ninsiima, Evelyn; Baryeija, Simon; Ouedraogo, Rasmata; Ye, Diarra; Traore, Hugues A; Nadembega, Christelle; Konate, Justin; Zongo, Arsene; Ouedraogo, Abass; Neboua, Desire; Belemvire, Aissatou; Bambara, Armel; Boncoungou, Justine; Zoungrana, Danielle; Nikodem, Cheryl; Harper, Kim; Jackson, Debra; Sanders, David; Sunday, Amwe; Okegbe-Eze, Collins; Williams, Xoliswa; Mshweshwe, Nolundi; Henge, Vatiswa; Gomba, Fikiswa; Nikodem, Lada; Khondowe, Oswell; Mwiya, Mwiya; Lusaka, Mildreed; Chizyuka, Mary; Phiri, Mary; Imakando, Billies; Musaku, Mwenechanya; Kapasa, Monica; Rutagwera, David; Clement, Ngondwe; Mwaba, Hilton Mwila; Matoba, Japhet; Mwaba, Hilton; Siumita, Chafye; Chola, Katai; Mwamutanda, Patricia (Peer reviewed; Journal article, 2017-05-09)
      Introduction: Breastfeeding is recommended for infants born to HIV-infected women in low-income settings. Both breastfeeding and HIV-infection are energy demanding. Our objective was to explore how exclusive and predominant ...
    • Clinical and Biological Factors Associated with Early Epstein-Barr Virus Infection in Human Immunodeficiency Virus-Exposed Uninfected Infants in Eastern Uganda 

      Montoya-Ferrer, Ana; Sanosyan, Armen; Fayd'Herbe De Maudave, Alexis; Pisoni, Amandine; Bollore, Karine; Molès, Jean-Pierre; Peries, Marianne; Tylleskär, Thorkild; Tumwine, James K.; Ndeezi, Grace; Gorgolas, Miguel; Nagot, Nicolas; Van De Perre, Philippe; Tuaillon, Edouard (Journal article; Peer reviewed, 2021)
      Background Immune control of Epstein-Barr virus (EBV) infection is impaired in individuals with HIV. We explored maternal factors associated with EBV acquisition in HIV-exposed uninfected (HEU) infants and the relationship ...
    • Design and challenges of a large HIV prevention clinical study on mother-to-child transmission: ANRS 12397 PROMISE-EPI study in Zambia and Burkina Faso 

      Mennecier, Anaïs; Kankasa, Chipepo; Fao, Paulin; Molès, Jean-Pierre; Eymard-Duvernay, Sabrina; Mwiya, Mwiya; Kania, Dramane; Chunda-Liyoka, Catherine; Sakana, Leticia; Rutagwera, David; Tassembedo, Souleymane; Wilfred-Tonga, Maria Melany; Mosqueira, Beatriz; Tylleskär, Thorkild; Nagot, Nicolas; Van De Perre, Philippe (Journal article; Peer reviewed, 2021)
      Post-natal HIV infection through breastfeeding remains a challenge in many low and middle-income countries, particularly due to non-availability of alternative infant feeding options and the suboptimal Prevention of Mother ...
    • Eliminating HIV transmission through breast milk from women taking antiretroviral drugs 

      Goga, Ameena; Van de Perre, Philippe; Ngandu, Nobubelo; Nagot, Nicolas; Abrams, Elaine J; Moodley, Dhayendre; King, Rachel; Molès, Jean-Pierre; Chirinda, Witness; Scarlatti, Gabriella; Tylleskär, Thorkild; Sherman, Gayle G; Pillay, Yogan; Dabis, François; Gray, Glenda (Journal article; Peer reviewed, 2021)
    • Eliminating postnatal HIV transmission in high incidence areas: need for complementary biomedical interventions 

      Van de Perre, Philippe; Goga, Ameena; Ngandu, Nobubelo; Nagot, Nicolas; Moodley, Dhayendre; King, Rachel; Molès, Jean-Pierre; Mosqueira, Beatriz; Chirinda, Witness; Scarlatti, Gabriella; Tylleskär, Thorkild; Dabis, François; Gray, Glenda (Journal article; Peer reviewed, 2021)
      The rate of mother-to-child transmission (MTCT) of HIV from breastfeeding is increasing relative to other causes of MTCT. Early effective preconception and antenatal antiretroviral therapy (ART) reduces intrauterine and ...
    • Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1‑year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life 

      Nagot, Nicolas; Singata-Madliki, Mandisa; Cournil, Amandine; Nalugya, Joyce; Tassembedo, Soleymane; Quillet, Catherine; Tonga, Melany W.; Tumwine, James K; Meda, Nicolas; Kankasa, Chipepo; Mwiya, Mwiya; Bangirana, Paul; Peries, Marianne; Batting, Joanne; Engebretsen, Ingunn Marie Stadskleiv; Tylleskär, Thorkild; Van de Perre, Philippe; Ndeezi, Grace; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      In the ANRS 12174 trial, HIV-exposed uninfected African neonates who received lopinavir-ritonavir (LPV/r) prophylaxis for 1 year exhibited slower growth from birth to week 50 compared with those receiving lamivudine (3TC). ...
    • HIV-1 disease progression in immune-competent HIV-1-infected and breastfeeding mothers participating in the ANRS 12174 clinical trial in Burkina Faso, South Africa, Uganda and Zambia: a cohort study 

      Some, Nagaonle Eric; Engebretsen, Ingunn Marie S.; Nagot, Nicolas; Meda, Nicolas; Vallo, Roselyne; Kankasa, Chipepo; Tumwine, James K; Singata, Mandisa; Harper, Kim; Hofmeyr, G. Justus; Perre, Philippe van de; Tylleskär, Thorkild (Peer reviewed; Journal article, 2018)
      Objective: We have assessed HIV-1 disease progression among HIV-1-positive mothers in relation to duration of any or exclusive breast feeding in the context of ANRS 12174 trial. Methods: The analysis was completed on 203, ...
    • Increased Epstein-Barr virus in breast milk occurs with subclinical mastitis and HIV shedding 

      Sanosyan, Armen; Rutagwera, David Gatsinzi; Moles, Jean-Pierre; Bollore, Karine; Peries, Marianne; Kankasa, Chipepo; Mwiya, Mwiya; Tylleskär, Thorkild; Nagot, Nicolas; Van de Perre, Philippe; Tuaillon, Edouard (Peer reviewed; Journal article, 2016-07)
      Epstein–Barr virus (EBV) in breast milk and subclinical mastitis (SCM) are both associated with human immunodeficiency virus (HIV) shedding and possibly with postnatal HIV transmission. The objective of this nested ...
    • Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis 

      Monnin, Audrey; Vizeneux, Amélie; Nagot, Nicolas; Eymard-Duvernay, Sabrina; Meda, Nicolas; Singata-Madliki, Mandisa; Ndeezi, Grace; Tumwine, James K; Kankasa, Chipepo; Goga, Ameena; Tylleskär, Thorkild; Van de Perre, Philippe; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of ...
    • Lopinavir/Ritonavir versus Lamivudine peri-exposure prophylaxis to prevent HIV-1 transmission by breastfeeding: the PROMISE-PEP trial Protocol ANRS 12174 

      Nagot, Nicolas; Kankasa, Chipepo; Meda, Nicolas; Hofmeyr, Justus; Nikodem, Cheryl; Tylleskär, Thorkild; Tumwine, James K.; Karamagi, Charles; Sommerfeldt, Halvor; Neveu, Dorine; Van de Perre, Philippe; for the PROMISE-PEP group (Peer reviewed; Journal article, 2012-10-06)
      Background: Postnatal transmission of HIV-1 through breast milk remains an unsolved challenge in many resource-poor settings where replacement feeding is not a safe alternative. WHO now recommends breastfeeding of infants ...
    • Mitochondrial DNA Instability Is Common in HIV-Exposed Uninfected Newborns 

      Monnin, Audrey; Desquiret-Dumas, Valérie; Meda, Nicolas; Goudenège, David; Bris, Céline; Kankasa, Chipepo; Singata-Madliki, Mandisa; Tylleskär, Thorkild; Procaccio, Vincent; Nagot, Nicolas; Van De Perre, Philippe; Reynier, Pascal; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      Worldwide, one million HIV-exposed uninfected (HEU) children are born yearly, and chronic health impairments have been reported in these children. Mitochondrial DNA (mtDNA) instability and altered mtDNA content have been ...
    • Prevalence and determinants of HIV shedding in breast milk during continued breastfeeding among Zambian mothers not on antiretroviral treatment (ART): A cross-sectional study 

      Rutagwera, David Gatsinzi; Molès, Jean-Pierre; Kankasa, Chipepo; Mwiya, Mwiya; Tuaillon, Edouard; Peries, Marianne; Nagot, Nicolas; Van de Perre, Philippe; Tylleskär, Thorkild (Peer reviewed; Journal article, 2019)
      The risk of postnatal HIV transmission exists throughout the breastfeeding period. HIV shedding in breast milk beyond six months has not been studied extensively. The aim of this study was to determine prevalence and ...