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The influence of CXCR4 on Maedi visna virus-induced syncytium formation

Bergen Open Research Archive

Show simple item record Hovden, Arnt-Ove 2006-03-02T09:27:08Z 2006-03-02T09:27:08Z 2001
dc.identifier.isbn 82-8088-003-8 (electronic version)
dc.description.abstract Maedi visna virus (MVV) is a retrovirus that is member of the Lentivirus genus. MVV infects sheep and goats and causes progressive pneumonia or paralysis, leading to death. Since the discovery of the receptor for Human immunodeficiency virus (HIV), Simian immunodeficiency virus (SIV) and Feline immunodeficiency virus (FIV) all include the chemokine receptor CXCR4, it has been postulated that all members of the Lentivirus share a common mechanism of entry that involves the use of CXCR4. With the use of syncytia assays, infection-, inhibition- and enhancement studies, it was shown that CXCR4 is not a common lentivirus receptor. U87 and HOS cells, both celllines lacking CXCR4, were susceptible to infection. However, cells transfected with CD4 and CXCR4 showed an increased syncytia formation and the presence of CD¤ and CXCR4 augments virus-induced cell fusion. The nature of MVV receptor is still not known, but our data suggest the use of CD4 and/or CXCR4 as accessory molecules or as part of a receptor complex. en
dc.format.extent 716235 bytes
dc.format.mimetype application/pdf
dc.language.iso eng en
dc.publisher The University of Bergen en
dc.rights Copyright the author. All rights reserved en
dc.title The influence of CXCR4 on Maedi visna virus-induced syncytium formation en
dc.type Master thesis
dc.subject.nsi VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473 no
dc.rightsHolder The author en
dc.subject.archivecode Mastergrad

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