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Trajectories of psychiatric disorders in a cohort of children with cerebral palsy across four years
(Journal article; Peer reviewed, 2021)Background: Risk of psychiatric disorders has been reported for children and adolescents with cerebral palsy (CP) at different ages, however little is known regarding the long-term trajectories of these disorders. Objective: ... -
Trajectories of psychological distress during recovery from polysubstance use disorder
(Journal article; Peer reviewed, 2021)Introduction: Polysubstance use is a prevalent substance use pattern with adverse effects on psychological distress and diminished treatment outcomes. Although polysubstance use often dominates clinical practice, the ... -
Transcranial direct current stimulation (tDCS) enhances internal source monitoring abilities in healthy participants
(Journal article; Peer reviewed, 2021-09-16)Source monitoring refers to the ability to identify the origin of a memory, for example, whether you remember saying something or thinking about it, and confusions of these sources have been associated with the experience ... -
Transcriptional adaptation in caenorhabditis elegans
(Journal article; Peer reviewed, 2020-01)Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed ... -
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
(Journal article; Peer reviewed, 2023)Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ... -
Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing
(Journal article; Peer reviewed, 2021)Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene. AIRE facilitates the expression of organ-specific ... -
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia
(Journal article; Peer reviewed, 2021)Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation and microRNAs (miRNAs) are involved. Here ... -
Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene
(Journal article; Peer reviewed, 2022)Arctic and sub-arctic pelagic organisms can be exposed to effluents and spills from offshore petroleum-related activities and thus it is important to understand how they respond to crude oil related contaminants such as ... -
Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects
(Journal article; Peer reviewed, 2021)Polar cod (Boreogadus saida) is a key species in the arctic marine ecosystem vulnerable to effects of pollution, particularly from petroleum related activities. To facilitate studying the effects of those pollutants, we ... -
Transcriptome-wide analyses of early immune responses in lumpfish leukocytes upon stimulation with poly(I:C)
(Journal article; Peer reviewed, 2023)Background: Both bacterial and viral diseases are a major threat to farmed fish. As the antiviral immune mechanisms in lumpfish (Cyclopterus lumpus L.) are poorly understood, lumpfish leukocytes were stimulated with ... -
A transcriptomic analysis of diploid and triploid Atlantic salmon lenses with and without cataracts
(Journal article; Peer reviewed, 2020)To avoid negative environmental impacts of escapees and potential inter-breeding with wild populations, the Atlantic salmon farming industry has and continues to extensively test triploid fish that are sterile. However, ... -
Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
(Journal article; Peer reviewed, 2023)Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ... -
Transcriptomic and targeted immune transcript analyses confirm localized skin immune responses in Atlantic salmon towards the salmon louse
(Journal article; Peer reviewed, 2023)Atlantic salmon (Salmo salar) are highly susceptible to infestations with the ectoparasite Lepeophtheirus salmonis, the salmon louse. Infestations elicit an immune response in the fish, but the response does not lead to ... -
Transcriptomic comparison of communally reared wild, domesticated and hybrid Atlantic salmon fry under stress and control conditions
(Journal article; Peer reviewed, 2020)Background Domestication is the process by which organisms become adapted to the human-controlled environment. Since the selection pressures that act upon cultured and natural populations differ, adaptations that favour ... -
Transcriptomic landscape of blood platelets in healthy donors
(Journal article; Peer reviewed, 2021)Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy ... -
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
(Journal article; Peer reviewed, 2022-06-02)Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ... -
The transcriptomic response of adult salmon lice (Lepeophtheirus salmonis) to reduced salinity
(Journal article; Peer reviewed, 2021)Salmon lice (Lepeophtheirus salmonis) are marine parasitic copepods living on salmonids and are challenging for salmon aquaculture. One of several treatment methods is the application of freshwater to the fish which can ... -
Transformation as relational mobilisation: The networked geography of Addis Ababa’s sustainable transport interventions
(Journal article; Peer reviewed, 2021)Literatures on sustainability transition and transformation increasingly emphasise the role of spatiality and local agency. This paper argues that relational thinking has much more to offer this debate than presently ... -
Transformative Translations? Challenges and tensions in territorial innovation governance
(Journal article; Peer reviewed, 2023)Since the 1990s, changing ways of producing and circulating knowledge have been accompanied by debates that diagnose and call for change in the relationship between science, society, politics, and innovation. Most recently ... -
Transforming knowledge systems for life on Earth: Visions of future systems and how to get there
(Journal article; Peer reviewed, 2020)Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of ...