Blar i Faculty of Mathematics and Natural Sciences på emneord "Enzyme"
Viser treff 1-5 av 5
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Binding Leverage as a Molecular Basis for Allosteric Regulation
(Peer reviewed; Journal article, 2011-09-15)Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures the ... -
Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
(Peer reviewed; Journal article, 2011-12-08)Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are visited ... -
Functional characterisation of three human nicotinamide mononucleotide adenylyltransferases
(Doctoral thesis, 2008-08-25)Nicotinamide adenine dinucleotide, NAD, is an essential redox factor in many, primarily catabolic, hydrogen transfer reactions. While the redox reactions are not accompanied by a net loss of the pyridine nucleotides, NAD+ ... -
A geometry-based generic predictor for catalytic and allosteric sites
(Peer reviewed; Journal article, 2011)An important aspect of understanding protein allostery, and of artificial effector design, is the characterization and prediction of substrate- and effector-binding sites. To find binding sites in allosteric enzymes, many ... -
Stabilisation of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy
(Master thesis, 2012-02-27)The aim of this thesis has been to characterise nanoparticles (NPs) to which tyrosine hydroxylase (TH) was attached, as a preliminary step in their evaluation to be used for an enzyme replacement therapy (ERT) for Parkinson's ...