Browsing Department of Biological Sciences by Author "Arnesen, Victoria Smith"

Now showing items 1-4 of 4

    • Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer 

      Mazloumi Gavgani, Fatemeh; Arnesen, Victoria Smith; Jacobsen, Rhian Gaenor; Krakstad, Camilla; Høivik, Erling Andre; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2018-12-07)
      The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ...

    • Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins 

      Gavgani, Fatemeh Mazloumi; Slinning, Malene Skuseth; Morovicz, Andrea Papdine; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; D'Santos, Clive S.; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)
      Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin ...

    • Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells 

      Mazloumi Gavgani, Fatemeh; Karlsson, Thomas; Tangen, Ingvild Løberg; Papdine Morovicz, Andrea; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; Spang, Katharina Maria; Krakstad, Camilla; Guillermet-Guibert, Julie; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)
      The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α and p110β are ubiquitously expressed but differently targeted in tumours. In cancer, PIK3CB (encoding p110β) is seldom mutated compared with PIK3CA ...

    • Role of the class I PI3K p110ß and PtdIns(3,4,5)P3 in rRNA transcription in the nucleolus 

      Arnesen, Victoria Smith (Master thesis, 2018-06-26)
      The phosphoinositide 3-kinase (PI3K) signalling pathway is one of the most altered pathways in human cancer. It is a complex pathway, when considering that ubiquitously expressed isoforms regulate different routes with ...