Blar i Department of Biological Sciences på forfatter "Bril'kov, Maxim"
-
Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix
Bril'kov, Maxim; Dobrovolska, Olena; Ødegård-Fougner, Øyvind; Turcu, Diana Cornelia; Strømland, Øyvind; Underhaug, Jarl; Aasland, Rein; Halskau, Øyvind (Journal article; Peer reviewed, 2022-04-13)The CW domain binds to histone tail modifications found in different protein families involved in epigenetic regulation and chromatin remodeling. CW domains recognize the methylation state of the fourth lysine on histone ... -
Conformational selection mechanism of ASHH2 methyltransferase CW domain recognising H3K4me1 histone modification
Bril'kov, Maxim (Doctoral thesis, 2020-10-26)From simple double-stranded molecule DNA is packed in the nucleus via different intermediate structures with help of various proteins organizing a complex structure referred to as chromatin. A subunit of chromatin is a ...