Browsing Department of Clinical Science by Title
Now showing items 1339-1358 of 2340
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Long-term temporal trends in incidence rate and case fatality of sepsis and COVID-19-related sepsis in Norwegian hospitals, 2008-2021: a nationwide registry study
(Journal article; Peer reviewed, 2023)Objectives: To estimate temporal trends in incidence rate (IR) and case fatality during a 14-year period from 2008 to 2021, and to assess possible shifts in these trends during the COVID-19 pandemic. Setting: All Norwegian ... -
Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
(Peer reviewed; Journal article, 2012-06-27)Background: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated ... -
A longitudinal follow-up of autoimmune polyendocrine syndrome type 1
(Peer reviewed; Journal article, 2016-08)Context: Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insufficiency, and ... -
A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease
(Journal article; Peer reviewed, 2022-05-12)Background: Few studies have examined the stability of the pulmonary mycobiome. We report longitudinal changes in the oral and pulmonary mycobiome of participants with and without COPD in a large-scale bronchoscopy study ... -
Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia
(Journal article; Peer reviewed, 2024)Background Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate ... -
Longterm follow-up in European respiratory health studies - patterns and implications
(Peer reviewed; Journal article, 2014-04-16)Background: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection ... -
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
(Journal article; Peer reviewed, 2022)Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase the risk for schizophrenia. Using CRISPR-Cas9, we ... -
Low BMI, but not high BMI, influences the timing of puberty in boys
(Journal article; Peer reviewed, 2021)Background Previous studies investigating the association between weight status and onset of puberty in boys have been equivocal. It is currently unclear to what extent weight class influences puberty onset and ... -
Low expression levels of ATM may substitute for CHEK2 / TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer
(Peer reviewed; Journal article, 2012-03-15)Introduction: Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNAdamaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and ... -
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
(Journal article; Peer reviewed, 2020)Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ... -
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
(Journal article; Peer reviewed, 2023)Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ... -
Low Levels of the Omega-3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase
(Peer reviewed; Journal article, 2011-01-14)In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ... -
Low myocardial energetic efficiency is associated with increased mortality in aortic stenosis
(Journal article; Peer reviewed, 2021)Objectives In hypertension, low myocardial energetic efficiency (MEEi) has been documented as an integrated marker of metabolic and left ventricular (LV) myocardial dysfunction. We tested the predictive performance of MEEi ... -
Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure
(Journal article; Peer reviewed, 2020-01-13)Introduction: In pregnancies after a previous cesarean section (CS), a planned repeat CS delivery has been associated with excess risk of adverse outcome. However, also the alternative, a trial of labor after CS (TOLAC), ... -
Low serum DHEA-S is associated with impaired lung function in women
(Journal article; Peer reviewed, 2020)Background Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. ... -
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
(Peer reviewed; Journal article, 2019-03-01)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ... -
Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen
(Journal article; Peer reviewed, 2021)Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ... -
Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism
(Peer reviewed; Journal article, 2016-12-04)The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to ... -
Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells
(Journal article; Peer reviewed, 2020)The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ... -
The lower airway microbiota and inflammation in chronic obstructive pulmonary disease (COPD) : Thoughts on where to measure it, how to interpret it, and why it might matter
(Doctoral thesis, 2024-02-01)Bakgrunn: Kronisk obstruktiv lungesjukdom (KOLS) er ein kompleks, inflammatorisk sjukdom som forårsakar millionar av dødsfall årleg. Bakteriane i dei nedre luftvegane (mikrobiotaet) og immunresponsar kan spele ei viktig ...