Blar i Bergen Open Research Archive på forfatter "Langeland, Nina"
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Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients
Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Zhou, Fan; Madsen, Anders Aasgaard; Onyango, Therese Bredholt; Fjelltveit, Elisabeth Berg; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Cantoni, Diego; Mayora-Neto, Martin; Temperton, Nigel; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)Background Neutralizing antibodies are important for protection against the pandemic SARS-CoV-2 virus, and long-term memory responses determine the risk of re-infection or boosting after vaccination. T-cellular responses ... -
Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors
Bruun, Trond; Oppegaard, Oddvar; Hufthammer, Karl Ove; Langeland, Nina; Skrede, Steinar (Peer reviewed; Journal article, 2016)Background: Skin and soft tissue infections are common reasons for medical care. Use of broad-spectrum therapy and costs have increased. Assessment of early treatment response has been given a central role both in clinical ... -
emm gene diversity, superantigen gene profiles and presence of SlaA among clinical isolates of group A, C and G streptococci from western Norway
Kittang, Bård Reiakvam; Skrede, Steinar; Langeland, Nina; Haanshuus, Christel Gill; Mylvaganam, Haima (Peer reviewed; Journal article, 2010-11-20)In order to investigate molecular characteristics of beta-hemolytic streptococcal isolates from western Norway, we analysed the entire emm gene sequences, obtained superantigen gene profiles and determined the prevalence ... -
Epidemiology and impact on all-cause mortality of sepsis in Norwegian hospitals: A national retrospective study
Knoop, Siri Tandberg; Skrede, Steinar; Langeland, Nina; Flaatten, Hans (Peer reviewed; Journal article, 2017-11-17)Background: Although sepsis is the leading cause of death from infection, there are few population-level epidemiological sepsis reports. The impact of sepsis-related deaths on all-cause hospital mortality is insufficiently ... -
Evaluation of immune responses in HIV infected patients with pleural tuberculosis by the QuantiFERON® TB-Gold interferon-gamma assay
Baba, Kamaldeen; Sørnes, Steinar; Hoosen, Anwar A.; Lekabe, Jacob M.; Mpe, Mathew J.; Langeland, Nina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2008-03-14)Background: Diagnosis of tuberculous (TB) pleuritis is difficult and better diagnostic tools are needed. New blood based interferon-gamma (IFN-γ) tests are promising, but sensitivity could be low in HIV positive patients. ... -
Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward
Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzaeg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A.; Nataro, James P.; Guttormsen, Anne Berit (Peer reviewed; Journal article, 2014-09-04)Background: Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea in resource-limited regions. It is also an important cause of diarrhea in travellers to these areas. To evaluate the protective ... -
Fever in the tropics: aetiology and case-fatality - a prospective observational study in a tertiary care hospital in South India
Abrahamsen, Siri Kratter; Haugen, Cathrine Nødtvedt; Rupali, Priscilla; Mathai, Dilip; Langeland, Nina; Eide, Geir Egil; Mørch, Kristine (Peer reviewed; Journal article, 2013-07-30)Background: The objective of this study was to describe aetiology and case fatality of fever among inpatients in a tertiary care hospital in South India. Methods: This was an observational, prospective study conducted in ... -
First identification of bla NDM-5 producing Escherichia coli from neonates and a HIV infected adult in Tanzania
Manyahi, Joel; Moyo, Sabrina John; Kibwana, Upendo; Goodman, Richard N.; Allman, Ellie; Hubbard, Alasdair T.M.; Blomberg, Bjørn; Langeland, Nina; Roberts, Adam P. (Journal article; Peer reviewed, 2022)Introduction. Carbapenem-resistant members of the family Enterobacteriaceae are emerging as a global public-health threat and cause substantial challenges in clinical practice. Gap Statement. There is a need for increased ... -
Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania
Kibwana, Upendo O.; Manyahi, Joel; Sandnes, Helene Heitmann; Blomberg, Bjørn; Mshana, Stephen E.; Langeland, Nina; Roberts, Adam P.; Moyo, Sabrina John (Journal article; Peer reviewed, 2023-03-07)Background: Fluoroquinolones have been, and continue to be, routinely used for treatment of many bacterial infections. In recent years, most parts of the world have reported an increasing trend of fluoroquinolone resistant ... -
Gastrointestinal colonization of extended-spectrum beta-lactamase-producing bacteria among children below five years of age hospitalized with fever in Dar es Salaam, Tanzania
Kibwana, Upendo O.; Manyahi, Joel; Sandnes, Helene Heitmann; Blomberg, Bjørn; Mshana, Stephen E.; Langeland, Nina; Moyo, Sabrina John (Journal article; Peer reviewed, 2022)Objectives: Gastrointestinal colonization of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) is of concern because prior colonization increases risk for subsequent infections. To date, the link between ... -
Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania
Manyahi, Joel; Moyo, Sabrina John; Langeland, Nina; Blomberg, Bjørn (Journal article; Peer reviewed, 2023-02-20)Background: Over one million yearly deaths are attributable to Streptococcus pneumoniae and people living with HIV are particularly vulnerable. Emerging penicillin non-susceptible Streptococcus pneumoniae (PNSP) challenges ... -
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia
Saghaug, Christina Skår; Gamlem, Astrid Leinebø; Hauge, Kirsti Brugrand; Vahokoski, Juha; Klotz, Christian; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt (Journal article; Peer reviewed, 2023)The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ... -
Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination
Moyo, Sabrina John; Blomberg, Bjørn; Hanevik, Kurt; Kommedal, Øyvind; Vainio, Kirsti; Maselle, Samwel Y.; Langeland, Nina (Peer reviewed; Journal article, 2014-05-20)Background: Tanzania currently rolls out vaccination against rotavirus-diarrhea, a major cause of child illness and death. As the vaccine covers a limited number of rotavirus variants, this study describes the molecular ... -
Genetic diversity of the flavohemoprotein gene of Giardia lamblia: Evidence for high allelic heterozygosity and copy number variation
Saghaug, Christina Skår; Klotz, Christian; Kallio, Juha Pekka; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt (Journal article; Peer reviewed, 2020)Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ... -
Genetic relatedness and risk factor analysis of ampicillin-resistant and high-level gentamicin-resistant enterococci causing bloodstream infections in Tanzanian children
Aamodt, Håvard; Mohn, Stein Christian; Maselle, Samuel Y; Manji, Karim P.; Willems, Rob; Jureen, Roland; Langeland, Nina; Blomberg, Bjørn (Peer reviewed; Journal article, 2015-02-28)Background While enterococci resistant to multiple antimicrobials are spreading in hospitals worldwide, causing urinary tract, wound and bloodstream infections, there is little published data on these infections from Africa. ... -
Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical giardia lamblia assemblage A and B isolates
Saghaug, Christina Skår; Klotz, Christian; Kallio, Juha Pekka; Brattbakk, Hans-Richard; Stokowy, Tomasz; Aebischer, Toni; Kursula, Inari; Langeland, Nina; Hanevik, Kurt (Peer reviewed; Journal article, 2019-05-10)Purpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways ... -
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
Hanevik, Kurt; Kristoffersen, Einar; Mørch, Kristine; Rye, Kristin Paulsen; Sørnes, Steinar; Svärd, Staffan; Bruserud, Øystein; Langeland, Nina (Peer reviewed; Journal article, 2017-01-28)Background: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. ... -
High prevalence of faecal carriage of ESBL-producing enterobacteriaceae among children in Dar es Salaam, Tanzania
Tellevik, Marit Gjerde; Blomberg, Bjørn; Kommedal, Øyvind; Maselle, Samuel Y; Langeland, Nina; Moyo, Sabrina John (Peer reviewed; Journal article, 2016-12-09)Background: Faecal carriage of ESBL-producing bacteria is a potential risk for transmission and infection. Little is known about faecal carriage of antibiotic resistance in Tanzania. This study aimed to investigate the ... -
High prevalence of fecal carriage of extended spectrum β-lactamase-producing enterobacteriaceae among newly HIV-diagnosed adults in a community setting in Tanzania
Manyahi, Joel; Moyo, Sabrina John; Tellevik, Marit Gjerde; Langeland, Nina; Blomberg, Bjørn (Journal article; Peer reviewed, 2020)Colonization in HIV-infected populations with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) is particularly worrisome in low-income settings. This study describes the prevalence of ESBL-PE carriage ... -
High rate of antimicrobial resistance and multiple mutations in the dihydrofolate reductase gene among Streptococcus pneumoniae isolated from HIV-infected adults in a community setting in Tanzania
Manyahi, Joel; Moyo, Sabrina John; Aboud, Said; Langeland, Nina; Blomberg, Bjørn (Journal article; Peer reviewed, 2020)Objectives: The aim of this study was to characterize molecular mechanisms of resistance to trimethoprim and other antibiotics in Streptococcus pneumoniae isolates from HIV-infected adults in Dar es Salaam, Tanzania. Methods: ...