Blar i Bergen Open Research Archive på tittel

Viser treff 22126-22145 av 34576

    • A novel collaboration platform: Structuring books as networks 

      Steensen, Ole Eskild (Master thesis, 2018-08-21)
      Ever since Gutenberg introduced the art of printing in Europe in the mid 1400s, the way we consume and author books has remained somewhat static. In spite of several technological advances since that time, the very structure ...

    • A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study 

      Frisk, Bente; Njøten, Kiri Lovise; Aarli, Bernt Bøgvald; Hystad, Sigurd William; Rykken, Sidsel; Kjosås, Ane; Søfteland, Eirik; Kvale, Gerd (Journal article; Peer reviewed, 2022)
      Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ...

    • A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 

      Lam, M.; Coppola, S.; Krumbach, Oliver H.F.; Prencipe, Giuseppe; Insalaco, Antonella; Cifaldi, C.; Brigida, I.; Zara, Erika; Scala, Serena; Di Cesare, Silvia; Martinelli, Simone; Di Rocco, Martina; Pascarella, Antonia; Niceta, Marcello; Pantaleoni, Francesca; Ciolfi, Andrea; Netter, Petra; Carisey, Alexandre; Diehl, Michael; Akbarzadeh, Mohammad; Conti, Francesca; Merli, Pietro; Pastore, Anna; Mortera, Stefano Levi; Camerini, Serena; Farina, L; Buchholzer, Marcel; Pannone, L.; Cao, T.; Coban-Akdemir, Zeynep H.; Jhangiani, Shalini N.; Muzny, Donna M.; Gibbs, Richard A.; Basso-Ricci, L.; Chiriaco, M.; Dvorsky, Radovan; Putignani, L.; Carsetti, Rita; Janning, Petra; Stray-Pedersen, Asbjørg; Erichsen, Hans Christian; Horne, AnnaCarin; Bryceson, Yenan; Torralba-Raga, Lamberto; Ramme, Kim; Rosti, Vittorio; Bracaglia, Claudia; Messia, Virginia; Palma, Paolo; Finocchi, Andrea; Lupski, James R. (Peer reviewed; Journal article, 2019)
      Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common ...

    • Novel endoscopic and MRI-based methods for evaluating exocrine pancreatic function in pancreatitis and monogenic forms of diabetes 

      Tjora, Erling (Doctoral thesis, 2013-11-15)
      Background: Monogenic diabetes (Maturity onset diabetes in the young, MODY) are autosomal dominantly inherited diabetes syndromes characterized by diabetes due to beta cell dysfunction, with typical onset of diabetes before ...

    • A Novel Evolutionary Solution Approach for Many-objective Reliability-Redundancy Allocation Problem Based on Objective Prioritization and Constraint Optimization 

      Nath, Rahul (Journal article; Peer reviewed, 2024)
      The reliability redundancy allocation problem (RRAP) has been mostly solved either as a single or as a multi-objective optimization problem. However, this problem also has numerous important constraints which play prominent ...

    • A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis 

      Ydreborg, Magdalena; Lisovskaja, Vera; Lagging, Martin; Christensen, Peer Brehm; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Wejstål, Rune; Norkrans, Gunnar; Lindh, Magnus; Färkkilä, Martti; Westin, Johan (Peer reviewed; Journal article, 2014-04-03)
      Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ...

    • A novel Geriatric Assessment frailty score predicts two-year mortality after Transcatheter Aortic Valve implantation 

      Skaar, Elisabeth; Eide, Leslie Sofia Pareja; Norekvål, Tone M.; Ranhoff, Anette Hylen; Nordrehaug, Jan Erik; Forman, Daniel E.; Schönenberger, Anders; Hufthammer, Karl Ove; Kuiper, Karel Kier-Jan; Bleie, Øyvind; Haaverstad, Rune; Schaufel, Margrethe Aase; Packer, Erik Jerome Stene; Langørgen, Jørund (Peer reviewed; Journal article, 2018-10-31)
      Aims Established surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify patients ...

    • A novel GFP nude rat model to investigate tumor-stroma interactions 

      Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2014-12-21)
      Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...

    • Novel GHB-derived natural products from European mistletoe (Viscum album) 

      Amer, Bashar; Juvik, Ole-Johan; Francis, George William; Fossen, Torgils (Peer reviewed; Journal article, 2013)
      Context: The European white-berry mistletoe [Viscum album L. (Loranthaceae)] is among the oldest known medicinal plants. At present the most important application of mistletoe extracts is in the treatment of cancer. However, ...

    • A novel human NatA N-alpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1) 

      Arnesen, Thomas; Gromyko, Darina; Kagabo, Diane; Betts, Matthew J.; Starheim, Kristian Kobbenes; Varhaug, Jan Erik; Anderson, Dave; Lillehaug, Johan (Peer reviewed; Journal article, 2009-05-29)
      Background: Protein acetylation is among the most common protein modifications. The two major types are post-translational Nε-lysine acetylation catalyzed by KATs (Lysine acetyltransferases, previously named HATs (histone ...

    • Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing 

      Tjensvoll, Kjersti; Lapin, Morten; Gilje, Bjørnar; Garresori, Herish; Oltedal, Satu; Forthun, Rakel Brendsdal; Molven, Anders; Rozenholc, Yves; Nordgård, Oddmund (Journal article; Peer reviewed, 2022)
      Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. ...

    • Novel inflammatory biomarkers in thyroid eye disease 

      Ueland, Hans Olav; Ueland, Grethe Åstrøm; Løvås, Kristian; Breivik, Lars Ertesvåg; Thrane, Alexander Stanley; Stokland, Ann-Elin Meling; Rødahl, Eyvind; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2022)
      Purpose: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves' disease (GD). Methods: Patients with GD ...

    • Novel Insights into Integrin α11 Expression and Function 

      Alam, Jahedul (Doctoral thesis, 2020-01-31)
      Integrins are a major group of cell surface receptors, which link the extracellular matrix with the cell cytoskeleton. They are heterodimeric proteins consisting of non- covalently bound α- and β-subunits. By regulating ...

    • Novel Insights into the Pathogenesis of Human Post-Primary Tuberculosis from Archival Material of the Pre-Antibiotic Era, 1931–1947 

      Riaz, Syeda Mariam; Hanevik, Kurt; Helgeland, Lars; Sviland, Lisbet; Hunter, Robert L.; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)
      Objectives: Primary and post-primary tuberculosis (TB) are distinct entities. The aim of this study was to study the histopathology of primary and post-primary TB by using the unique human autopsy material from the ...

    • Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment 

      Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-02)
      Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve ...

    • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits 

      Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Curtin, John A.; Lakka, Timo A.; Grarup, Niels; Scholz, Markus; van der Most, Peter J.; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O.; Vilor-Tejedor, Natalia; Cousminer, Diana L.; Standl, Marie; Wang, Carol A.; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M.; Zafarmand, Mohammed H.; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N.; Have, Christian T.; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M.; Barroso, Inês; Bønnelykke, Klaus; Beilin, Lawrence J.; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clément, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G.; Vaudel, Marc; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2020)
      The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...

    • A novel measure of non-coding genome conservation identifies genomic regulatory blocks within primates 

      Nash, Alexander J.; Lenhard, Boris (Journal article; Peer reviewed, 2018-12-07)
      Motivation Clusters of extremely conserved non-coding elements (CNEs) mark genomic regions devoted to cis-regulation of key developmental genes in Metazoa. We have recently shown that their span coincides with that of ...

    • Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescenceactivated cell sorting 

      Poli, Aurélie; Brons, Nicolaas H.C.; Ammerlaan, Wim; Michel, Tatiana; Hentges, François; Chekenya, Martha; Zimmer, Jacques (Peer reviewed; Journal article, 2010-11)
      Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the ...

    • Novel Methods and Sources for Regeneration of Oral Mucosa 

      Das, Ridhima (Doctoral thesis, 2022-06-16)
      Background: Common clinical approaches for replacing damaged oral mucosa are represented by autologous skin grafts which have numerous shortcomings and pose serious post-surgical morbidity. Cultured oral mucosal sheets ...

    • Novel Methods Using Human Emotion and Visual Features for Recommending Movies 

      Johannessen, Øyvind (Master thesis, 2021-06-01)
      This master thesis investigates novel methods using human emotion as contextual information to estimate and elicit ratings when watching movie trailers. The aim is to acquire user preferences without the intrusive and ...