Browsing Bergen Open Research Archive by Title
Now showing items 20372-20391 of 34139
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The Molecular Epidemiology of Enterovirus in a Birth Cohort in Nepal
(Journal article; Peer reviewed, 2023)Acute gastroenteritis (AGE) has a major impact on morbidity and mortality worldwide. The viral aetiology of diarrhoeal diseases may remain unknown due to limited diagnostic facilities. Non-polio enteroviruses (NPEVs) are ... -
Molecular evidence for a single origin of ultrafiltration-based excretory organs
(Journal article; Peer reviewed, 2021)Excretion is an essential physiological process, carried out by all living organisms, regardless of their size or complexity.1, 2, 3 Both protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea ... -
Molecular evidence of parallel evolution in a cyanophage
(Journal article; Peer reviewed, 2023)Antagonistic interactions between bacteriophage (phage) and its bacterial host drives the continual selection for resistance and counter-defence. To date, much remains unknown about the genomic evolution that occurs as ... -
Molecular evidence that only two opsin subfamilies, the blue light- (SWS2) and green light-sensitive (RH2), drive color vision in Atlantic cod (Gadus morhua)
(Peer reviewed; Journal article, 2014-12-31)Teleosts show a great variety in visual opsin complement, due to both gene duplication and gene loss. The repertoire ranges from one subfamily of visual opsins (scotopic vision) including rod opsin only retinas seen in ... -
Molecular gut content analysis demonstrates that Calanus grazing on Phaeocystis pouchetii and Skeletonema marinoi is sensitive to bloom phase but not prey density
(Peer reviewed; Journal article, 2016-01-19)Mesozooplankton grazing selection in complex marine microbial communities is a poorly understood yet critical structuring component of marine microbial food webs. We wished to quantitatively assess how relative grazing by ... -
Molecular identification and first demographic insights of sharks based on artisanal fisheries bycatch in the Pacific Coast of Colombia: implications for conservation
(Journal article; Peer reviewed, 2022)The Pacific coast of Colombia is characterized by mangrove ecosystems which play a crucial role as possible nurseries for juvenile sharks. However, trophic food webs from coastal ecosystems are heavily disturbed by increased ... -
The Molecular Machinery of Gametogenesis in Geodia Demosponges (Porifera): Evolutionary Origins of a Conserved Toolkit across Animals
(Journal article; Peer reviewed, 2020)All animals are capable of undergoing gametogenesis. The ability of forming haploid cells from diploid cells through meiosis and recombination appeared early in eukaryotes, whereas further gamete differentiation is mostly ... -
Molecular markers to predict prognosis and guide therapy in endometrial cancer
(Doctoral thesis, 2020-02-07)Background: Endometrial cancer is the most common gynecological malignancy in the Western world. The disease occurs in the epithelial lining of the uterus, called the endometrium. Although prognosis is good and most of the ... -
Molecular mechanisms governing development of the hindbrain choroid plexus and auditory projection: A validation of the seminal observations of Wilhelm His
(Journal article; Peer reviewed, 2022)Studies by His from 1868 to 1904 delineated the critical role of the dorsal roof plate in the development of the hindbrain choroid plexus, and of the rhombic lips in the development of hindbrain auditory centers. Modern ... -
Molecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins
(Peer reviewed; Journal article, 2014)DNA, RNA and proteins are major biological macromolecules that coevolve and adapt to environments as components of one highly interconnected system. We explore here sequence/structure determinants of mechanisms of adaptation ... -
Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2
(Peer reviewed; Journal article, 2017-07-26)Charcot-Marie-Tooth (CMT) disease is one of the most common inherited neuropathies. Recently, three CMT1-associated point mutations (I43N, T51P, and I52T) were discovered in the abundant peripheral myelin protein P2. These ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
(Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Molecular mechanisms of sonoporation in cancer therapy : Optimization of sonoporation parameters and investigations of intracellular signalling
(Doctoral thesis, 2020-06-17)Background: Sonoporation, which is treatment with ultrasound (US) and microbubbles (MB), has shown great potential for enhancing the therapeutic efficacy of chemotherapy in cancer therapy. However, there is still very ... -
Molecular oxygen-assisted in defect-rich ZnO for catalytic depolymerization of polyethylene terephthalate
(Journal article; Peer reviewed, 2023)Polyethylene terephthalate (PET) is the most produced polyester plastic; its waste has a disruptive impact on the environment and ecosystem. Here, we report a catalytic depolymerization of PET into bis(2-hydroxyethyl) ... -
Molecular pathogenesis of polymerase gamma-related neurodegeneration
(Peer reviewed; Journal article, 2014-07)Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ... -
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
(Journal article, 2021)Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ... -
Molecular patterning during the development of Phoronopsis harmeri reveals similarities to rhynchonelliform brachiopods
(Journal article; Peer reviewed, 2019)Background: Phoronids, rhynchonelliform and linguliform brachiopods show striking similarities in their embryonic fate maps, in particular in their axis specification and regionalization. However, although brachiopod ... -
Molecular phylogenies challenge the classification of Polymastiidae (Porifera, Demospongiae) based on morphology
(Peer reviewed; Journal article, 2016)Polymastiidae Gray, 1867 is a worldwide distributed sponge family, which has a great significance for understanding of the demosponge deep phylogeny since the former order Hadromerida Topsent, 1894 has been recently split ... -
Molecular phylogeny of bark and ambrosia beetles reveals multiple origins of fungus farming during periods of global warming
(Peer reviewed; Journal article, 2012-08-01)Background: Fungus farming is an unusual life style in insects that has evolved many times in the wood boring weevils named ‘ambrosia beetles’. Multiple occurrences of this behaviour allow for a detailed comparison of the ...