Browsing Bergen Open Research Archive by Title
Now showing items 25419-25438 of 34322
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The protein N-alpha-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells
(Peer reviewed; Journal article, 2009-03-02)Background: The hNaa10p (hArd1) protein is the catalytic subunit of the human NatA Nα- terminal acetyltransferase complex. The NatA complex is associated with ribosomes and cotranslationally acetylates human proteins ... -
Protein Post-Translational Modification Crosstalk in Acute Myeloid Leukemia Calls for Action
(Peer reviewed; Journal article, 2019)Background: Post-translational modification (PTM) crosstalk is a young research field. However, there is now evidence of the extraordinary characterization of the different proteoforms and their interactions in a biological ... -
Protein profiling reveals inter-individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid
(Peer reviewed; Journal article, 2011-05-20)Background: The mechanisms behind formation and filling of intracranial arachnoid cysts (AC) are poorly understood. The aim of this study was to evaluate AC fluid by proteomics to gain further knowledge about ACs. Two goals ... -
Protein target highlights in CASP15: Analysis of models by structure providers
(Journal article; Peer reviewed, 2023)We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively ... -
Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database
(Peer reviewed; Journal article, 2011-01)Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ... -
Proteogenomics in Microbiology: Taking the Right Turn at the Junction of Genomics and Proteomics
(Peer reviewed; Journal article, 2014-12)High-accuracy and high-throughput proteomic methods have completely changed the way we can identify and characterize proteins. MS-based proteomics can now provide a unique supplement to genomic data and add a new level of ... -
Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease
(Journal article; Peer reviewed, 2021)All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ... -
Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ... -
Proteome changes in Atlantic cod (Gadus morhua) exposed to oil and produced water: discovery of biomarker candidates for environmental monitoring
(Doctoral thesis, 2007-09-07)Produced water is the most dominating source of continuous oil discharges to the sea offshore. It contains a wide range of compounds such as alkyl phenols, polyaromatic hydrocarbons (PAHs), heavy metals, carboxylic acids ... -
Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats
(Peer reviewed; Journal article, 2014-08-16)Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ... -
Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin
(Journal article; Peer reviewed, 2023)Secretomes of mesenchymal stromal cells (MSCs) are emerging as a novel growth factor (GF)-based strategy for periodontal and bone regeneration. The objective of this study was to compare the secretome of human bone marrow ... -
Proteomic analysis of neonatal meningitis-causing Escherichia coli
(Master thesis, 2017-11-30)Meningitis in newborns is a serious infection that causes mortality and neurological injury worldwide. The infection progresses from sepsis, and is dependent on the pathogen being able to cross the blood-brain barrier and ... -
Proteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: A pilot study from Zanzibar, Tanzania
(Journal article; Peer reviewed, 2023)This study aimed at exploring the proteomic profile of PBMCs to predict treatment response in pulmonary tuberculosis (PTB). This was a pilot study conducted among 8 adult patients from Zanzibar, Tanzania with confirmed ... -
Proteomic analysis of total cellular proteins of human neutrophils
(Peer reviewed; Journal article, 2009-08-31)Background: Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ... -
Proteomic Analysis of Zebrafish Protein Recoding via mRNA Editing by ADAR Enzymes
(Journal article; Peer reviewed, 2022)RNA editing by adenosine deaminases of the ADAR family can lead to protein recoding, since inosine formed from adenosine in mRNA is complementary to cytosine; the resulting codon editing might introduce amino acid substitutions ... -
Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease
(Journal article; Peer reviewed, 2023)Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ... -
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers
(Peer reviewed; Journal article, 2019-07-31)Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ... -
A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case
(Peer reviewed; Journal article, 2009-03-03)Background: Neuropeptide ligands have to fit exactly into their respective receptors and thus the evolution of the coding regions of their genes is constrained and may be strongly conserved. As such, they may be suitable ... -
Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells
(Journal article; Peer reviewed, 2021)Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ... -
Proteomic Profiling of Primary Human Acute Myeloid Leukemia Cells Does Not Reflect Their Constitutive Release of Soluble Mediators
(Peer reviewed; Journal article, 2018-12-20)Acute myeloid leukemia (AML) is a heterogeneous disease, and communication between leukemic cells and their neighboring leukemia-supporting normal cells is involved in leukemogenesis. The bone marrow cytokine network is ...