Blar i Bergen Open Research Archive på forfatter "Ballard, Clive"
-
COSMOS-improving the quality of life in nursing home patients: Protocol for an effectiveness-implementation cluster randomized clinical hybrid trial
Husebø, Bettina; Flo, Elisabeth; Aarsland, Dag; Selbæk, Geir; Testad, Ingelin; Gulla, Christine; Aasmul, Irene; Ballard, Clive (Peer reviewed; Journal article, 2015-09-15)Background: Nursing home patients have complex mental and physical health problems, disabilities and social needs, combined with widespread prescription of psychotropic drugs. Preservation of their quality of life is an ... -
Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial
Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Oesterhus, Ragnhild; Dalen, Ingvild; Larsen, Alf Inge; Fladby, Tormod; Brooker, Helen; Wesnes, Keith A.; Ballard, Clive; Aarsland, Dag (Journal article; Peer reviewed, 2020)Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ... -
Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM)
Erdal, Ane; Flo, Elisabeth; Aarsland, Dag; Ballard, Clive; Slettebø, Dagrun Daltveit; Husebø, Bettina (Peer reviewed; Journal article, 2018-06)Background Chronic pain and depression often co-occur, and pain may exacerbate depression in people with dementia. Objective The objective of this study was to assess the efficacy and safety of analgesic treatment for ... -
Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial
Husebø, Bettina Sandgathe; Ballard, Clive; Fritze, Friederike; Sandvik, Reidun Karin; Aarsland, Dag (Peer reviewed; Journal article, 2014-08)Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact ... -
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Peer reviewed; Journal article, 2019-10-22)Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ... -
High prevalence of orthostatic hypotension in mild dementia
Sønnesyn, Hogne; Nilsen, Dennis W. T.; Rongve, Arvid; Nore, Sabine; Ballard, Clive; Tysnes, Ole-Bjørn; Aarsland, Dag (Peer reviewed; Journal article, 2009-11)Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild ... -
Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: A cluster randomized trial
Sandvik, Reidun Karin; Selbæk, Geir; Seifert, Reinhard; Aarsland, Dag; Ballard, Clive; Corbett, Anne; Husebø, Bettina Sandgathe (Peer reviewed; Journal article, 2014-05-13)Background: Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome. Methods: Three hundred fifty-two ... -
LIVE@Home.Path--innovating the clinical pathway for home-dwelling people with dementia and their caregivers: Study protocol for a mixed-method, stepped-wedge, randomized controlled trial
Husebø, Bettina; Allore, Heather; Achterberg, Wilco; Angeles, Renira Corinne; Ballard, Clive; Bruvik, Frøydis Kristine; Fæø, Stein Erik; Gedde, Marie H.; Hillestad, Eirin; Jacobsen, Frode F.; Kirkevold, Øyvind; Kjerstad, Egil; Kjome, Reidun Lisbet Skeide; Mannseth, Janne; Naik, Mala; Nouchi, Rui; Puaschitz, Nathalie; Samdal, Rune; Tranvåg, Oscar; Tzoulis, Charalampos; Vahia, Ipsit Vihang; Vislapuu, Maarja; Berge, Line Iden (Journal article; Peer reviewed, 2020)Background The global health challenge of dementia is exceptional in size, cost and impact. It is the only top ten cause of death that cannot be prevented, cured or substantially slowed, leaving disease management, caregiver ... -
A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia
Aarsland, Dag; Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Holteng, Lise Birgitte Austbø; Oesterhus, Ragnhild; Nakling, Arne; Jarholm, Jonas Alexander; de Lucia, Chiara; Fladby, Tormod; Brooker, Helen; Dalen, Ingvild; Ballard, Clive (Journal article; Peer reviewed, 2023)Importance Identifying nutritional compounds which can reduce cognitive decline in older people is a hugely important topic. Objective To study the safety and effect of anthocyanins in maintaining cognitive functioning ... -
Self-reported sleep fragmentation and sleep duration and their association with cognitive function in PROTECT, a large digital community-based cohort of people over 50
Aakre, Jon Arild; Schulz, Jörn; Ballard, Clive; Corbett, Anne; Bjorvatn, Bjørn; Aarsland, Dag; Creese, Byron; Hampshire, Adam; Brooker, Helen; Testad, Ingelin (Journal article; Peer reviewed, 2023)Objective: Sleep is vital for normal cognitive function in daily life, but is commonly disrupted in older adults. Poor sleep can be detrimental to mental and physical health, including cognitive function. This study assessed ... -
Tolerability of buprenorphine transdermal system in nursing home patients with advanced dementia: a randomized, placebo-controlled trial (DEP.PAIN.DEM)
Erdal, Ane; Flo, Elisabeth; Aarsland, Dag; Selbæk, Geir; Ballard, Clive; Slettebø, Dagrun Daltveit; Husebø, Bettina (Peer reviewed; Journal article, 2018-05-16)Purpose: Buprenorphine transdermal system is increasingly prescribed in people with advanced dementia, but no clinical trial has investigated the safety and factors associated with discontinuation due to adverse events in ...