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High prevalence of orthostatic hypotension in mild dementia

Sønnesyn, Hogne; Nilsen, Dennis W. T.; Rongve, Arvid; Nore, Sabine; Ballard, Clive; Tysnes, Ole-Bjørn; Aarsland, Dag
Peer reviewed, Journal article
Accepted version
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URI
https://hdl.handle.net/1956/8596
Date
2009-11
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  • Department of Clinical Science [1083]
Original version
https://doi.org/10.1159/000247586
Abstract
Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild dementia were diagnosed according to consensus criteria after comprehensive standardised assessment. OH and QTc were assessed using standardised criteria. Results: OH was significantly more common in the dementia than in the control group, and systolic drop was higher in those with Dementia with Lewy bodies. There were no significant differences in QTc values between dementia and control subjects. Conclusion: OH occurs even in patients with mild dementia, in particular in DLB. QTc was not prolonged in patients with mild dementia compared with normal controls.
Publisher
Karger
Journal
Dementia and Geriatric Cognitive Disorders
Copyright
Copyright 2009 S. Karger AG, Basel

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