Browsing Bergen Open Research Archive by Author "Cox, Rebecca Jane"
Now showing items 1-20 of 30
-
Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self-reported severity and duration of illness
Tunheim, Gro; Laake, Ida; Robertson, Anna Hayman; Waalen, Kristian; Hungnes, Olav; Næss, Lisbeth Meyer; Cox, Rebecca Jane; Mjaaland, Siri; Trogstad, Lill (Peer reviewed; Journal article, 2018-12-09)Background: A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy. Objectives: We studied maternal ... -
Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years
Trieu, Mai Chi; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Sridhar, Saranya; Mjaaland, Siri; Cox, Rebecca Jane (Peer reviewed; Journal article, 2018-08-14)Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ... -
Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination
Mohn, Kristin Greve Isdahl; Zhou, Fan; Brokstad, Karl Albert; Sridhar, Saranya; Cox, Rebecca Jane (Peer reviewed; Journal article, 2017-05)Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept ... -
Common nodes of virus-host interaction revealed through an integrated network analysis
Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2019-10-04)Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ... -
Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination
Tete, Sarah; Krammer, Florain; Jalloh, Sarah Larteley Lartey; Bredholt, Geir; Wood, John M.; Skrede, Steinar; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-07-28)Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ... -
Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy
Savic, Miloje; Dembinski, Jennifer Lynn; Laake, Ida; Hungnes, Olav; Cox, Rebecca Jane; Oftung, Fredrik; Trogstad, Lill; Mjaaland, Siri (Peer reviewed; Journal article, 2017-11-16)Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not ... -
A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza
Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne; Grødeland, Gunnveig (Peer reviewed; Journal article, 2017-12)Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ... -
Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children
Mohn, Kristin Greve Isdahl; Brokstad, Karl Albert; Islam, Shahinul; Oftung, Fredrik; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ... -
Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP
Pedersen, Gabriel Kristian; Ebensen, Thomas; Gjeraker, Ingrid Hjetland; Svindland, Signe; Bredholt, Geir; Guzmán, Carlos Alberto; Cox, Rebecca Jane (Peer reviewed; Journal article, 2011-11-01)Avian influenza A H5N1 is a virus with pandemic potential. Mucosal vaccines are attractive as they have the potential to block viruses at the site of entry, thereby preventing both disease and further transmission. The ... -
Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward
Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzaeg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A.; Nataro, James P.; Guttormsen, Anne Berit (Peer reviewed; Journal article, 2014-09-04)Background: Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea in resource-limited regions. It is also an important cause of diarrhea in travellers to these areas. To evaluate the protective ... -
The expression of B & T cell activation markers in children’s tonsils following live attenuated influenza vaccine
Panapasa, Jack A.; Cox, Rebecca Jane; Mohn, Kristin Greve Isdahl; Aqrawi, Lara Adnan; Brokstad, Karl Albert (Peer reviewed; Journal article, 2015-07-06)Live attenuated influenza vaccines (LAIV) can prevent influenza illness and death in children. The absence of known correlates of protection induced by LAIV requires human studies of underlying mechanisms of vaccine-induced ... -
High prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopia
Dembinski, Jennifer Lynn; Mihret, Adane; Yimer, Solomon Abebe; Tessema, Bamlak; Trieu, Mai Chi; Tarekegn, Azeb; Getachew, Nahom; Cox, Rebecca Jane; Oftung, Fredrik; Haneberg, Bjørn; Aseffa, Abraham; Mjaaland, Siri (Peer reviewed; Journal article, 2017-01)Background. Influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. However, new evidence suggests that it significantly impacts hospitalization and promotes ... -
Immune Responses in Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the 2009 Influenza Pandemic in Norway
Mohn, Kristin Greve Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M; Mjaaland, Siri (Peer reviewed; Journal article, 2015-11-25)Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during ... -
Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines
Sridhar, Saranya; Brokstad, Karl Albert; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-04-24)Influenza is a major respiratory pathogen causing annual outbreaks and occasional pandemics. Influenza vaccination is the major method of prophylaxis. Currently annual influenza vaccination is recommended for groups at ... -
Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge
Mann, Alex; Noulin, Nicolas; Catchpole, Andrew; Stittelaar, Koert J.; De Waal, Leon; Veldhuis Kroeze, Edwin J.B.; Hinchcliffe, Michael; Smith, Alan; Montomoli, Emanuele; Piccirella, Simona; Osterhaus, Albert D.M. E.; Knight, Alastair; Oxford, John S.; Lapini, Giulia; Cox, Rebecca Jane; Lambkin-Williams, Rob (Peer reviewed; Journal article, 2014-05-21)We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret ... -
Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge
Major, Diane; Chichester, Jessica A.; Pathirana, Rishi; Guilfoyle, Kate; Shoji, Yoko; Guzman, Carlos A.; Yusibov, Vidadi; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-05)Highly pathogenic avian influenza H5N1 infection remains a public health threat and vaccination is the best measure of limiting the impact of a potential pandemic. Mucosal vaccines have the advantage of eliciting immune ... -
Live attenuated influenza vaccine in children induces b-cell responses in tonsils
Mohn, Kristin Greve Isdahl; Brokstad, Karl Albert; Pathirana, Rishi; Bredholt, Geir; Jul-Larsen, Åsne; Trieu, Mai Chi; Jalloh, Sarah Larteley Lartey; Montemoli, Emanuele; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016)Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ... -
Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction
Jalloh, Sarah Larteley Lartey; Zhou, Fan; Brokstad, Karl Albert; Mohn, Kristin Greve Isdahl; Slettevoll, Steffen Aleksander; Pathirana, Rishi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)Background Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ... -
Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children
Mohn, Kristin Greve Isdahl; Bredholt, Geir; Brokstad, Karl Albert; Pathirana, Rishi; Aarstad, Hans Jørgen; Tøndel, Camilla; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-05-15)Background. The live attenuated influenza vaccine (LAIV) is the preferred vaccine for children, but the mechanisms behind protective immune responses are unclear, and the duration of immunity remains to be elucidated. This ... -
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca Jane; Tenson, Tanel; Merits, Andres; Kainov, Denis (Peer reviewed; Journal article, 2019-03-01)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ...