Blar i Bergen Open Research Archive på forfatter "Finne-Wistrand, Anna"
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Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells cultured in 3D Copolymer Scaffolds Enhances Bone Formation
Sharma, Sunita; Sapkota, Dipak; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Bruland, Ove; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-01-25)Selection of appropriate osteoinductive growth factors, suitable delivery method and proper supportive scaffold are critical for a successful outcome in bone tissue engineering using bone marrow stromal cells (BMSC). This ... -
Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect
Sharma, Sunita; Xue, Ying; Xing, Zhe; Yassin, Mohammed Ahmed; Sun, Yang; Lorens, James; Finne-Wistrand, Anna; Sapkota, Dipak; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-04-11)Apart from osteogenesis, neovascularization of the defect area is an important determinant for successful bone healing. Accordingly, several studies have employed the combined delivery of VEGFA and BMP2 for bone regeneration. ... -
Altered surface hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells
Xing, Zhe; Cai, Jiazheng; Sun, Yang; Cao, Mengnan; Li, Yi; Xue, Ying; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)Background: Recent studies have suggested that both poly(l-lactide-co-1,5-dioxepan-2-one) (or poly(LLA-co-DXO)) and poly(l-lactide-co-ε-caprolactone) (or poly(LLA-co-CL)) porous scaffolds are good candidates for use as ... -
Angiogenic and Immunomodulatory Properties of Endothelial and Mesenchymal Stem Cells
Bartaula-Brevik, Sushma; Pedersen, Torbjørn Østvik; Finne-Wistrand, Anna; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-02)It has been suggested that the effect of implanted cells on the local environment is important when selecting the appropriate cell type for tissue regeneration. Our aim was to compare the local tissue response to implanted ... -
Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration
Yassin, Mohammed Ahmed; Leknes, Knut N.; Pedersen, Torbjørn Østvik; Xing, Zhe; Sun, Yang; Lie, Stein Atle; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2015-11)Constructs intended for bone tissue engineering (TE) are influenced by the initial cell seeding density. Therefore, the objective of this study was to determine the effect of bone marrow stromal stem cells (BMSCs) density ... -
Comparison of bone regenerative capacity of donor-matched human adipose–derived and bone marrow mesenchymal stem cells
Mohamed Ahmed, Samih; Yassin, Mohammed Ahmed; Elsebahy, Ahmad Rashad Saad Mohamed; Espedal, Heidi; Idris, Shaza Bushra M.; Finne-Wistrand, Anna; Vindenes, Hallvard; Mustafa, Kamal Babikeir Eln; Fristad, Inge (Journal article; Peer reviewed, 2020-11)Adipose-derived stem cells (ASC) have been used as an alternative to bone marrow mesenchymal stem cells (BMSC) for bone tissue engineering. However, the efficacy of ASC in bone regeneration in comparison with BMSC remains ... -
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds
Liu, Hailong; Ahlinder, Astrid; Yassin, Mohammed Ahmed; Finne-Wistrand, Anna; Gasser, T. (Journal article; Peer reviewed, 2020)Degradable porous polymeric structures are attractive candidates for biological tissue scaffolds, and adequate mechanical, transport, chemical and biological properties determine their functionality. Aside from the properties ... -
Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model
Sharma, Sunita; Sapkota, Dipak; Xue, Ying; Rajthala, Saroj; Yassin, Mohammed Ahmed Alamin Yousif; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2018-01-31)Background: In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influence ... -
Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration
Munir, Arooj; Døskeland, Anne; Avery, Steven J; Fuoco, Tiziana; Mohamed Ahmed, Samih; Lygre, Henning; Finne-Wistrand, Anna; Sloan, Alastair J; Waddington, Rachel J; Mustafa, Kamal Babikeir Eln; Suliman, Salwa (Journal article; Peer reviewed, 2019)Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after ... -
Endochondral Ossification Induced by Cell Transplantation of Endothelial Cells and Bone Marrow Stromal Cells with Copolymer Scaffold Using a Rat Calvarial Defect Model
Xing, Zhe; Jiang, Xiaofeng; Si, Qingzong; Finne-Wistrand, Anna; Liu, Bin; Xue, Ying; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)It has been recently reported that, in a rat calvarial defect model, adding endothelial cells (ECs) to a culture of bone marrow stromal cells (BMSCs) significantly enhanced bone formation. The aim of this study is to further ... -
Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs
Pedersen, Torbjørn Østvik; Blois, Anna L; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James B.; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2013-05-17)Introduction: A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic ... -
Engineering 3D degradable, pliable scaffolds toward adipose tissue regeneration; optimized printability, simulations and surface modification
Jain, Shubham; Yassin, Mohammed Ahmed; Fuoco, Tiziana; Liu, Hailong; Mohamed Ahmed, Samih; Mustafa, Kamal Babikeir Eln; Finne-Wistrand, Anna (Journal article; Peer reviewed, 2020)We present a solution to regenerate adipose tissue using degradable, soft, pliable 3D-printed scaffolds made of a medical-grade copolymer coated with polydopamine. The problem today is that while printing, the medical grade ... -
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ... -
Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration
Suliman, Salwa; Mieszkowska, Anna; Folkert, Justyna; Rana, Neha; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fuoco, Tiziana; Finne-Wistrand, Anna; Dirscherl, Kai; Jørgensen, Bodil; Mustafa, Kamal Babikeir Elnour; Gurzawska-Comis, Katarzyna (Journal article; Peer reviewed, 2022)Background Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly ... -
In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2
Suliman, Salwa; Sun, Yang; Pedersen, Torbjørn Østvik; Xue, Ying; Nickel, Joachim; Waag, Thilo; Finne-Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Costea, Daniela Elena; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-03)The aim is to evaluate the effect of modifying poly[(l-lactide)-co-(ε-caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or with nDP+physisorbed BMP-2 (nDP+BMP-2) on in vivo host tissue response and degradation. The ... -
Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling
Bartaula-Brevik, Sushma; Pedersen, Torbjorn Østvik; Blois, Anna L; Papadakou, Panagiota; Finne-Wistrand, Anna; Xue, Ying; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2014-12-20)Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial ... -
Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation
Pedersen, Torbjørn Østvik; Blois, Anna L; Xue, Ying; Xing, Zhe; Sun, Yang; Finne-Wistrand, Anna; Lorens, James B.; Fristad, Inge; Leknes, Knut N.; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2014-02-17)Introduction: Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular cells assemble into a complex regulating ... -
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes
Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Krueger, Anke; Steinmüller-Nethl, Doris; Finne-Wistrand, Anna; Osdal, Tereza; Osman, Amani Hamza Ali; Sun, Yang; Parajuli, Himalaya; Waag, Thilo; Nickel, Joachim; Johannessen, Anne Christine; McCormack, Emmet; Costea, Daniela Elena (Peer reviewed; Journal article, 2016-07)This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance ...