Browsing Bergen Open Research Archive by Author "Gilhus, Nils Erik"
Now showing items 1-18 of 18
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AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study
Hong, Yu; Liang, Kristina Xiao; Gilhus, Nils Erik (Journal article; Peer reviewed, 2020-07-08)Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, ... -
Are MRI high-signal changes of alar and transverse ligaments in acute whiplash injury related to outcome?
Vetti, Nils; Kråkenes, Jostein; Eide, Geir Egil; Rørvik, Jarle; Gilhus, Nils Erik; Espeland, Ansgar (Peer reviewed; Journal article, 2010-11-11)Background: Upper neck ligament high-signal changes on magnetic resonance imaging (MRI) have been found in patients with whiplash-associated disorders (WAD) but also in non-injured controls. The clinical relevance of such ... -
Complicating autoimmune diseases in myasthenia gravis: A review
Nacu, Aliona; Andersen, Jintana Bunpan; Lisnic, Vitalie; Owe, Jone Furulund; Gilhus, Nils Erik (Peer reviewed; Journal article, 2015-04-27)Myasthenia gravis (MG) is a rare autoimmune disease of skeletal muscle endplates. MG subgroup is relevant for comorbidity, but usually not accounted for. MG patients have an increased risk for complicating autoimmune ... -
Interictal epileptiform discharges vary across age groups
Aanestad, Eivind; Gilhus, Nils Erik; Brøgger, Jan (Journal article; Peer reviewed, 2020-01)Objective To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods 10,547 patients who had a standard or sleep deprived EEG recording reported ... -
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study
Husebye, Elisabeth Synnøve Nilsen; Gilhus, Nils Erik; Spigset, Olav; Daltveit, Anne Kjersti; Bjørk, Marte-Helene (Peer reviewed; Journal article, 2020)Background and purpose: The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods: The study ... -
Late Onset Myasthenia Gravis Is Associated with HLA DRB1*15:01 in the Norwegian Population
Maniaol, Angelina H.; Elsais, Ahmed; Lorentzen, Åslaug R.; Owe, Jone F.; Viken, Marte K.; Gilhus, Nils Erik (Peer reviewed; Journal article, 2012-05-09)Background: Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic ... -
Maternal complications in pregnancy and childbirth for women with epilepsy: time trends in a nationwide cohort
Danielsson, Kim Christian; Gilhus, Nils Erik; Borthen, Ingrid; Lie, Rolv T.; Morken, Nils-Halvdan (Peer reviewed; Journal article, 2019)Objective: Obstetric trends show changes in complication rates and maternal characteristics such as caesarean section, induced labour, and maternal age. To what degree such general time trends and changing patterns of ... -
Myasthenia gravis can have consequences for pregnancy and the developing child
Gilhus, Nils Erik (Journal article; Peer reviewed, 2020)Myasthenia gravis (MG) with onset below 50 years, thymic hyperplasia and acetylcholine receptor (AChR) antibodies is more common in females than in males. For a relatively large group of MG patients, pregnancy represents ... -
Perinatal Depression and Anxiety in Women with Multiple Sclerosis: A Population-Based Cohort Study
Eid, Karine; Torkildsen, Øivind Fredvik Grytten; Aarseth, Jan Harald; Flemmen, Heidi Øyen; Holmøy, Trygve; Lorentzen, Åslaug Rudjord; Myhr, Kjell-Morten; Riise, Trond; Simonsen, Cecilia Smith; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Willumsen, Johannes Sverre; Øksendal, Nina; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)Objective: To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS). Methods: 114,629 pregnant women were included in the Norwegian Mother, Father and Child ... -
Physical training and exercise in myasthenia gravis
Gilhus, Nils Erik (Journal article; Peer reviewed, 2021)Myasthenia gravis is characterized by muscle weakness and fatigue. As sustained muscle use increases the weakness, the value of physical training programs has previously been questioned. This is a review to clarify the ... -
Polio and post-polio syndrome in non-Western immigrants: A new challenge for the healthcare system in Norway
Festvåg, Lillian; Stanghelle, Johan K; Gilhus, Nils Erik; Rike, Per-Ola; Schanke, Anne-Kristine (Peer reviewed; Journal article, 2019)Objective: To explore the health situation and identify specific health challenges in non-Western immigrants with polio in Norway, by comparing their status with Western immigrants with polio and native Norwegians with ... -
Psychiatric Comorbidity, Social Aspects and Quality of Life in a Population-Based Cohort of Expecting Fathers with Epilepsy
Reiter, Simone B. C. Frizell; Veiby, Gyri; Bjørk, Marte Helene; Engelsen, Bernt; Daltveit, Anne Kjersti; Gilhus, Nils Erik (Peer reviewed; Journal article, 2015-12-04)Objectives. To investigate psychiatric disorders, adverse social aspects and quality of life in men with epilepsy during partner’s pregnancy. Method. We used data from the Norwegian Mother and Child Cohort Study, including ... -
Repeated acetylcholine receptor antibody-concentrations and association to clinical myasthenia gravis development
Heldal, Anne Taraldsen; Eide, Geir Egil; Romi, Fredrik Robert; Owe, Jone Furulund; Gilhus, Nils Erik (Peer reviewed; Journal article, 2014-12-02)Introduction: We aimed to examine the longitudinal association between Myasthenia Gravis (MG) clinical severity and concentration of acetylcholine receptor (AChR)-antibodies to evaluate if AChR-antibody variations correlate ... -
Total drug treatment and comorbidity in myasthenia gravis: a population-based cohort study
Andersen, Jintana Bunpan; Owe, Jone Furulund; Engeland, Anders; Gilhus, Nils Erik (Peer reviewed; Journal article, 2014-04-09)Background and purpose: Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a ... -
Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuro-psychiatric symptoms in the offspring of parents with epilepsy
Bjørk, Marte Helene; Veiby, Gyri; Spigset, Olav; Gilhus, Nils Erik (Peer reviewed; Journal article, 2014-12-29)Introduction: Antiepileptic drug (AED) teratogenicity is suspected to be the main cause of impaired development in children of women with epilepsy. However, many factors may confound the reported risks. The purpose of this ... -
Verbal abilities in children of mothers with epilepsy: Association to maternal folate status
Husebye, Elisabeth Synnøve Nilsen; Gilhus, Nils Erik; Riedel, Bettina; Spigset, Olav; Daltveit, Anne Kjersti; Bjørk, Marte-Helene (Peer reviewed; Journal article, 2018-08)Objective: To examine the effect of maternal folic acid supplementation and maternal plasma folate and antiepileptic drug (AED) concentrations on language delay in AED-exposed children of mothers with epilepsy. Methods: ... -
Young people with epilepsy have an increased risk of eating disorder and poor quality diet
Kolstad, Eivind; Bjørk, Marte Helene; Gilhus, Nils Erik; Alfstad, Kristin Åshild; Clench-Aas, Jocelyne; Lossius, Morten (Peer reviewed; Journal article, 2018-03)Objective: To investigate whether adolescents with epilepsy are at increased risk of having self‐reported eating disorder symptoms and poor quality diet compared to young people from the general population. Methods: We ... -
Zilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody–Positive Generalized Myasthenia Gravis
Howard, James F.; Vissing, John; Gilhus, Nils Erik; Leite, Maria Isabel; Utsugisawa, Kimiaki; Duda, Petra W.; Farzaneh-Far, Ramin; Murai, Hiroyuki; Wiendl, Heinz (Journal article; Peer reviewed, 2021)Generalized myasthenia gravis (gMG) is an autoimmune disorder in which pathogenic autoantibodies damage the neuromuscular junction, causing disabling or life-threatening muscle weakness. Most treatments nonspecifically ...