Browsing Bergen Open Research Archive by Author "Gilhus, Nils Erik"
Now showing items 1-20 of 27
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Abuse and revictimization in adulthood in multiple sclerosis: a cross-sectional study during pregnancy
Eid, Karine; Torkildsen, Øivind; Aarseth, Jan Harald; Celius, Elisabeth Gulowsen; Cortese, Marianna; Holmøy, Trygve; Kapali, Akash; Myhr, Kjell-Morten; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Background: Knowledge concerning exposure to abuse in adulthood and in pregnancy in people with multiple sclerosis (MS) is sparse. Objective: To determine the occurrence of adult abuse and abuse in relation to pregnancy ... -
AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study
Hong, Yu; Liang, Kristina Xiao; Gilhus, Nils Erik (Journal article; Peer reviewed, 2020-07-08)Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, ... -
Advances and challenges in the treatment of myasthenia gravis
Schneider-Gold, Christiane; Gilhus, Nils Erik (Journal article; Peer reviewed, 2021)Myasthenia gravis (MG) is a chronic autoimmune disease with fluctuating muscle weakness and fatigability. Standard immunomodulatory treatment may fail to achieve sufficient improvement with minimal symptom expression or ... -
Are MRI high-signal changes of alar and transverse ligaments in acute whiplash injury related to outcome?
Vetti, Nils; Kråkenes, Jostein; Eide, Geir Egil; Rørvik, Jarle; Gilhus, Nils Erik; Espeland, Ansgar (Peer reviewed; Journal article, 2010-11-11)Background: Upper neck ligament high-signal changes on magnetic resonance imaging (MRI) have been found in patients with whiplash-associated disorders (WAD) but also in non-injured controls. The clinical relevance of such ... -
Association of adverse childhood experiences with the development of multiple sclerosis
Eid, Karine; Torkildsen, Øivind; Aarseth, Jan Harald; Aalstad, Mari; Bhan, Alok; Celius, Elisabeth Gulowsen; Cortese, Marianna; Daltveit, Anne Kjersti Nesje; Holmøy, Trygve; Myhr, Kjell-Morten; Riise, Trond; Schuler, Stephan; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Objective To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development. Methods A nationwide, prospective cohort study based on participants ... -
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability
Bjørk, Marte-Helene; Zoega, Helga; Leinonen, Maarit K.; Cohen, Jacqueline Mallory; Dreier, Julie Werenberg; Furu, Kari; Gilhus, Nils Erik; Gissler, Mika; Halfdanarson, Oskar; Igland, Jannicke; Sun, Yuelian; Tomson, Torbjörn; Alvestad, Silje; Christensen, Jakob (Journal article; Peer reviewed, 2022)Importance: Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to AMSs is uncertain. Objective: To determine ... -
Complicating autoimmune diseases in myasthenia gravis: A review
Nacu, Aliona; Andersen, Jintana Bunpan; Lisnic, Vitalie; Owe, Jone Furulund; Gilhus, Nils Erik (Peer reviewed; Journal article, 2015-04-27)Myasthenia gravis (MG) is a rare autoimmune disease of skeletal muscle endplates. MG subgroup is relevant for comorbidity, but usually not accounted for. MG patients have an increased risk for complicating autoimmune ... -
Folic Acid and Risk of Preterm Birth, Preeclampsia, and Fetal Growth Restriction Among Women With Epilepsy A Prospective Cohort Study
Alvestad, Silje; Husebye, Elisabeth Synnøve Nilsen; Christensen, Jakob; Dreier, Julie Werenberg; Sun, Yuelian; Igland, Jannicke; Leinonen, Maarit; Gissler, Mika; Gilhus, Nils Erik; Tomson, Torbjörn; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Background and Objectives Women with epilepsy treated with antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction, and preeclampsia. We aimed to ... -
Interictal epileptiform discharges vary across age groups
Aanestad, Eivind; Gilhus, Nils Erik; Brøgger, Jan (Journal article; Peer reviewed, 2020-01)Objective To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods 10,547 patients who had a standard or sleep deprived EEG recording reported ... -
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study
Husebye, Elisabeth Synnøve Nilsen; Gilhus, Nils Erik; Spigset, Olav; Daltveit, Anne Kjersti; Bjørk, Marte-Helene (Peer reviewed; Journal article, 2020)Background and purpose: The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods: The study ... -
Late Onset Myasthenia Gravis Is Associated with HLA DRB1*15:01 in the Norwegian Population
Maniaol, Angelina H.; Elsais, Ahmed; Lorentzen, Åslaug R.; Owe, Jone F.; Viken, Marte K.; Gilhus, Nils Erik (Peer reviewed; Journal article, 2012-05-09)Background: Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic ... -
Maternal complications in pregnancy and childbirth for women with epilepsy: time trends in a nationwide cohort
Danielsson, Kim Christian; Gilhus, Nils Erik; Borthen, Ingrid; Lie, Rolv T.; Morken, Nils-Halvdan (Peer reviewed; Journal article, 2019)Objective: Obstetric trends show changes in complication rates and maternal characteristics such as caesarean section, induced labour, and maternal age. To what degree such general time trends and changing patterns of ... -
Myasthenia gravis can have consequences for pregnancy and the developing child
Gilhus, Nils Erik (Journal article; Peer reviewed, 2020)Myasthenia gravis (MG) with onset below 50 years, thymic hyperplasia and acetylcholine receptor (AChR) antibodies is more common in females than in males. For a relatively large group of MG patients, pregnancy represents ... -
Perinatal Depression and Anxiety in Women with Multiple Sclerosis: A Population-Based Cohort Study
Eid, Karine; Torkildsen, Øivind Fredvik Grytten; Aarseth, Jan Harald; Flemmen, Heidi Øyen; Holmøy, Trygve; Lorentzen, Åslaug Rudjord; Myhr, Kjell-Morten; Riise, Trond; Simonsen, Cecilia Smith; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Willumsen, Johannes Sverre; Øksendal, Nina; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)Objective: To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS). Methods: 114,629 pregnant women were included in the Norwegian Mother, Father and Child ... -
Physical training and exercise in myasthenia gravis
Gilhus, Nils Erik (Journal article; Peer reviewed, 2021)Myasthenia gravis is characterized by muscle weakness and fatigue. As sustained muscle use increases the weakness, the value of physical training programs has previously been questioned. This is a review to clarify the ... -
Plasma unmetabolized folic acid in pregnancy and risk of autistic traits and language impairment in antiseizure medication-exposed children of women with epilepsy
Husebye, Elisabeth Synnøve Nilsen; Wendel, Annabel Willemijn Karine; Gilhus, Nils Erik; Riedel, Bettina Maria Ingeborg; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Background: Fetal exposure to unmetabolized folic acid (UMFA) during pregnancy may be associated with adverse neurodevelopment. Antiseizure medication (ASM) may interact with folate metabolism. Women with epilepsy using ... -
Polio and post-polio syndrome in non-Western immigrants: A new challenge for the healthcare system in Norway
Festvåg, Lillian; Stanghelle, Johan K; Gilhus, Nils Erik; Rike, Per-Ola; Schanke, Anne-Kristine (Peer reviewed; Journal article, 2019)Objective: To explore the health situation and identify specific health challenges in non-Western immigrants with polio in Norway, by comparing their status with Western immigrants with polio and native Norwegians with ... -
Prevalence of self-reported emotional, physical, and sexual abuse and association with fear of childbirth in pregnant women with epilepsy: The Norwegian Mother, Father, and Child Cohort Study
Vederhus, Johannes; Husebye, Elisabeth Synnøve Nilsen; Eid, Karine; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)Objective This study was undertaken to examine the prevalence of self-reported experiences with abuse in pregnant women with epilepsy and the association between having experienced abuse and childbirth expectations, ... -
Psychiatric Comorbidity, Social Aspects and Quality of Life in a Population-Based Cohort of Expecting Fathers with Epilepsy
Reiter, Simone B. C. Frizell; Veiby, Gyri; Bjørk, Marte Helene; Engelsen, Bernt; Daltveit, Anne Kjersti; Gilhus, Nils Erik (Peer reviewed; Journal article, 2015-12-04)Objectives. To investigate psychiatric disorders, adverse social aspects and quality of life in men with epilepsy during partner’s pregnancy. Method. We used data from the Norwegian Mother and Child Cohort Study, including ... -
Repeated acetylcholine receptor antibody-concentrations and association to clinical myasthenia gravis development
Heldal, Anne Taraldsen; Eide, Geir Egil; Romi, Fredrik Robert; Owe, Jone Furulund; Gilhus, Nils Erik (Peer reviewed; Journal article, 2014-12-02)Introduction: We aimed to examine the longitudinal association between Myasthenia Gravis (MG) clinical severity and concentration of acetylcholine receptor (AChR)-antibodies to evaluate if AChR-antibody variations correlate ...