Browsing Bergen Open Research Archive by Author "Gjessing, Håkon K."
Now showing items 1-20 of 32
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Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with DMD, FGF13, EGFL6, and Additional Loci at Xp22.2
Skare, Øivind; Lie, Rolv T.; Haaland, Øystein Ariansen; Gjerdevik, Miriam; Romanowska, Julia; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-22)Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which ... -
Association of Household Income With Life Expectancy and Cause-Specific Mortality in Norway, 2005-2015
Kinge, Jonas Minet; Modalsli, Jørgen Heibø; Øverland, Simon Nygaard; Gjessing, Håkon K.; Tollånes, Mette Christophersen; Knudsen, Ann Kristin; Skirbekk, Vegard Fykse; Strand, Bjørn Heine; Håberg, Siri Eldevik; Vollset, Stein Emil (Peer reviewed; Journal article, 2019-05-13)Importance: Examining causes of death and making comparisons across countries may increase understanding of the income-related differences in life expectancy. Objectives: To describe income-related differences in life ... -
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ... -
Candidate gene analysis of spontaneous preterm delivery: New insights from re-analysis of a case-control study using case-parent triads and control-mother dyads
Myking, Solveig; Myhre, Ronny; Gjessing, Håkon K.; Morken, Nils-Halvdan; Sengpiel, Verena; Williams, Scott M.; Ryckman, Kelli K.; Magnus, Per; Jacobsson, Bo (Peer reviewed; Journal article, 2011-12-30)Background: Spontaneous preterm delivery (PTD) has a multifactorial etiology with evidence of a genetic contribution to its pathogenesis. A number of candidate gene case-control studies have been performed on spontaneous ... -
Design efficiency in genetic association studies
Gjerdevik, Miriam; Gjessing, Håkon K.; Romanowska, Julia; Haaland, Øystein Ariansen; Jugessur, Astanand; Czajkowski, Nikolai Olavi; Lie, Rolv T. (Journal article; Peer reviewed, 2020)Selecting the best design for genetic association studies requires careful deliberation; different study designs can be used to scan for different genetic effects, and each design has its own set of strengths and limitations. ... -
Effectiveness of mRNA booster vaccination against mild, moderate, and severe COVID-19 caused by the Omicron variant in a large, population-based, Norwegian cohort
Laake, Ida; Skodvin, Siri Nærland; Blix, Kristine; Caspersen, Ida Henriette; Gjessing, Håkon K.; Juvet, Lene Kristine; Magnus, Per Minor; Mjaaland, Siri; Robertson, Anna Hayman; Starrfelt, Jostein; Trogstad, Lill; Feiring, Berit (Journal article; Peer reviewed, 2022)Background Understanding how booster vaccination can prevent moderate and severe illness without hospitalization is crucial to evaluate the full advantage of mRNA boosters. Methods We followed 85 801 participants (aged ... -
Estimation of fetal weight in pregnancies past term
Eggebø, Torbjørn Moe; Klefstad, Olav-Andre; Økland, Inger; Lindtjørn, Elsa; Eik-Nes, Sturla; Gjessing, Håkon K. (Peer reviewed; Journal article, 2017-02)Introduction: The aim of the study was to investigate the accuracy of estimating fetal weight with ultrasound in pregnancies past term, using the eSnurra algorithm. Material and methods: In all, 419 women with pregnancy ... -
A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population
Denault, William Robert Paul; Romanowska, Julia; Helgeland, Øyvind; Jacobsson, Bo; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)Background Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW has increased dramatically since ... -
Gene-methylation interactions: Discovering region-wise DNA methylation levels that modify SNP-associated disease risk
Romanowska, Julia; Haaland, Øystein Ariansen; Jugessur, Astanand; Gjerdevik, Miriam; Xu, Zongli; Taylor, Jack A.; Wilcox, Allen J; Jonassen, Inge; Lie, Rolv T.; Gjessing, Håkon K. (Journal article; Peer reviewed, 2020)Background Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously. ... -
Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios
Haaland, Øystein Ariansen; Jugessur, Astanand; Gjerdevik, Miriam; Romanowska, Julia; Shi, Min; Beaty, Terri H.; Marazita, Mary L.; Murray, Jeffrey C.; Wilcox, Allen J.; Lie, Rolv T.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2017-09-12)Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease ... -
A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption
Haaland, Øystein Ariansen; Romanowska, Julia; Gjerdevik, Miriam; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2019-06-24)Background: Although both genetic and environmental factors have been reported to influence the risk of isolated cleft lip with or without cleft palate (CL/P), the exact mechanisms behind CL/P are still largely unaccounted ... -
A genome-wide search for gene-environment effects in isolated cleft lip with or without cleft palate triads points to an interaction between maternal periconceptional vitamin use and variants in ESRRG
Haaland, Øystein Ariansen; Lie, Rolv T.; Romanowska, Julia; Gjerdevik, Miriam; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-26)Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these ... -
Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls
Gjerdevik, Miriam; Jugessur, Astanand; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Cordell, Heather J.; Gjessing, Håkon K. (Peer reviewed; Journal article, 2019-04-02)Background: Log-linear and multinomial modeling offer a flexible framework for genetic association analyses of offspring (child), parent-of-origin and maternal effects, based on genotype data from a variety of child-parent ... -
A hierarchical frailty model applied to two-generation melanoma data
Moger, Tron Anders; Haugen, Marion; Yip, Benjamin H. K.; Gjessing, Håkon K.; Borgan, Ørnulf (Peer reviewed; Journal article, 2010)We present a hierarchical frailty model based on distributions derived from non-negative Lévy processes. The model may be applied to data with several levels of dependence, such as family data or other general clusters, ... -
Infection with SARS-CoV-2 during pregnancy and risk of stillbirth: a Scandinavian registry study
Magnus, Maria Christine; Örtqvist, Anne K.; Urhoj, Stine Kjaer; Aabakke, Anna; Mortensen, Laust Hvas; Gjessing, Håkon K.; Andersen, Anne-Marie Nybø; Stephansson, Olof; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2023)Background: A few studies indicate that women infected with SARS-CoV-2 during pregnancy might have an increased risk of stillbirth. Our aim was to investigate the risk of stillbirth according to infection with SARS-CoV-2 ... -
Intake of sucrose‑sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in ofspring: a Norwegian pregnancy cohort study
Grønning Dale, Maria Teresa; Magnus, Per; Leirgul, Elisabeth; Holmstrøm, Henrik; Gjessing, Håkon K.; Brodwall, Kristoffer; Haugen, Margaretha; Stoltenberg, Camilla; Øyen, Nina (Peer reviewed; Journal article, 2019)Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened ... -
Integral conditions for Skorohod stochastic differential equations
Gjessing, Håkon K. (Statistical report no. 24, Research report, 1994-06) -
Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data
Vefring, Hege K.; Wee, Line; Jugessur, Astanand; Gjessing, Håkon K.; Nilsen, Stein Tore; Lie, Rolv Terje (Peer reviewed; Journal article, 2010-06-10)Background Preeclampsia is a debilitating disorder affecting approximately 3% of pregnant women in the Western world. Although inconclusive, current evidence suggests that the renin-angiotensin system may be involved in ... -
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia
Jugessur, Astanand; Shi, Min; Gjessing, Håkon K.; Lie, Rolv Terje; Wilcox, Allen James; Weinberg, Clarice Ring; Christensen, Kaare; Boyles, Abee Lowman; Daack-Hirsch, Sandra; Nguyen, Truc Trung; Christiansen, Lene; Lidral, Andrew Carl; Murray, Jeffrey Clark (Peer reviewed; Journal article, 2010-07-09)Background Fetal conditions can in principle be affected by the mother's genotype working through the prenatal environment. Methodology/Principal Findings Genotypes for 1536 SNPs in 357 cleft candidate genes were available ... -
A new approach to chromosome-wide analysis of X-linked markers identifies new associations in Asian and European case-parent triads of orofacial clefts
Skare, Øivind; Gjessing, Håkon K.; Gjerdevik, Miriam; Haaland, Øystein Ariansen; Romanowska, Julia; Lie, Rolv T.; Jugessur, Astanand (Peer reviewed; Journal article, 2017-09-06)Background: GWAS discoveries on the X-chromosome are underrepresented in the literature primarily because the analytical tools that have been applied were originally designed for autosomal markers. Our objective here is ...