A hierarchical frailty model applied to two-generation melanoma data
Peer reviewed, Journal article
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We present a hierarchical frailty model based on distributions derived from non-negative Lévy processes. The model may be applied to data with several levels of dependence, such as family data or other general clusters, and is an alternative to additive frailty models. We present several parametric examples of the model, and properties such as expected values, variance and covariance. The model is applied to a case-cohort sample of age at onset for melanoma from the Swedish Multi-Generation Register,organized in nuclear families of parents and one or two children. We compare the genetic component of the total frailty variance to the common environmental term, and estimate the effect of birth cohort and gender.
OpphavsrettCopyright The Author(s) 2010. This article is published with open access at Springerlink.com
The Author(s) 2010