Blar i Bergen Open Research Archive på forfatter "Hollås, Hanne"

Viser treff 1-8 av 8

    • Annexin A2 binds the internal ribosomal entry site of c-myc mRNA and regulates its translation 

      Strand, Elin; Hollås, Hanne; Sakya, Siri Aastedatter; Romanyuk, Sofya; Saraste, Mikko Erik Vedeler; Grindheim, Ann Kari; Patil, Sudarshan S.; Vedeler, Anni (Journal article; Peer reviewed, 2021)
      The expression and localization of the oncoprotein c-Myc is highly regulated at the level of transcription, mRNA transport, translation, as well as stability of the protein. We previously showed that Annexin A2 (AnxA2) ...

    • The cooperative folding of annexin A2 relies on a transient nonnative intermediate 

      Hollås, Hanne; Ramirez, Juan; Nominé, Yves; Kostmann, Camille; Toto, Angelo; Gianni, Stefano; Travé, Gilles; Vedeler, Anni (Journal article; Peer reviewed, 2022)
      Annexins (Anxs) are a family of highly homologous proteins that bind and aggregate lipid vesicles in the presence of calcium. All members of the family contain a variable N-terminus determining specific functions, followed ...

    • The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects 

      Raddum, Aase Merethe; Hollås, Hanne; Shumilin, Igor; Henklein, Petra; Kretsinger, Robert; Fossen, Torgils; Vedeler, Anni (Peer reviewed; Journal article, 2015-03-13)
      The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ...

    • Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes 

      Aukrust, Ingvild; Rosenberg, Linn Andersen; Ankerud, Mia Madeleine; Bertelsen, Vibeke; Hollås, Hanne; Saraste, Jaakko; Grindheim, Ann Kari; Vedeler, Anni (Peer reviewed; Journal article, 2017-02)
      Various post-translational modifications (PTMs) regulate the localisation and function of the multifunctional protein Annexin A2 (AnxA2). In addition to its various tasks as a cytoskeletal- and membrane-associated protein, ...

    • Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2 

      Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni (Peer reviewed; Journal article, 2015-01-15)
      Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ...

    • RNA-binding is an ancient trait of the Annexin family 

      Patil, Sudarshan; Panchal, Vipul Navinchandra; Røstbø, Trude Kvalnes; Romanyuk, Sofya; Hollås, Hanne; Brenk, Ruth; Grindheim, Ann Kari; Vedeler, Anni (Journal article; Peer reviewed, 2023)
      Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of ...

    • Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment 

      Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)
      The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ...

    • Two tales of Annexin A2 knock-down: One of compensatory effects by antisense RNA and another of a highly active hairpin ribozyme 

      Aareskjold, Elin; Grindheim, Ann Kari; Hollås, Hanne; Goris, Marianne; Lillehaug, Johan R.; Vedeler, Anni (Peer reviewed; Journal article, 2019-05-31)
      Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the progression of many cancer types and also plays key roles during viral infection and multiplication. Consequently, there ...