Browsing Bergen Open Research Archive by Author "Vikse, Bjørn Egil"
Now showing items 1-20 of 21
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Addition of eGFR and age improves the prognostic absolute renal risk-model in 1,134 norwegian patients with IgA nephropathy
Knoop, Thomas; Vågane, Ann Merethe; Vikse, Bjørn Egil; Svarstad, Einar; Magnusdottir, Bergrun Tinna; Leh, Sabine Maria; Reisæter, Anna Varberg; Bjørneklett, Rune (Peer reviewed; Journal article, 2015-05)Background: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the ... -
Birth Weight Is Associated With Kidney Size in Middle-Aged Women
Lillås, Bjørn Steinar; Qvale, Tor Hatlestad; Richter, Blazej Konrad; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2021)Introduction Low birth weight (LBW) is associated with increased risk of kidney disease due to lower nephron endowment leading to hyperfiltration and subsequent nephron loss. Kidney size is commonly used as a proxy for ... -
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve?
Onsøien, Mari Olsen; Midtvedt, Karsten; Reisæter, Anna Varberg; Aasarød, Knut; Waldum-Grevbo, Bård; Vikse, Bjørn Egil; Eriksen, Bjørn Odvar; Åsberg, Anders (Journal article; Peer reviewed, 2021)Background. Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach ... -
Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli
Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine Maria; Osman, Tarig Al-Hadi; Marti, Hans-Peter; Berven, Frode; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2019-11-14)Background IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN. Methods In ... -
End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population
Skrunes, Rannveig; Svarstad, Einar; Reisæter, Anna Varberg; Marti, Hans-Petter; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2016-11-09)Background: Increased risk of end stage renal disease (ESRD) and death in Norwegian living kidney donors has been reported, most of the donors were related to the recipient. The present study investigates risk of death in ... -
Exposure to mycophenolate and fatherhood
Midtvedt, Karsten; Bergan, Stein; Reisæter, Anna Varberg; Vikse, Bjørn Egil; Åsberg, Anders (Peer reviewed; Journal article, 2017-07)Background: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium, and it is widely used after organ transplantation. In women, taking MPA is teratogenic ... -
Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life
Gjerde, Anna; Skrunes, Rannveig; Reisæter, Anna Varberg; Marti, Hans Peter; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2021)Introduction: Previous studies have revealed that individuals with low birth weight (LBW) have higher risk of chronic kidney disease (CKD) and that LBW and CKD cluster in families. This study investigates how familial ... -
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine Maria; Marti, Hans-Peter; Mollnes, Tom Eirik; Berven, Frode; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2017-08-14)Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with ... -
Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts
Kipp, Anne; Marti, Hans Peter; Babickova, Janka; Nakken, Sigrid; Leh, Sabine; Strøm Halden, Thea Anine; Jenssen, Trond; Vikse, Bjørn Egil; Åsberg, Anders; Spagnoli, Giulio; Furriol, Jessica (Journal article; Peer reviewed, 2023)Background Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM ... -
Intrauterine growth restriction and risk of diverse forms of kidney disease during the first 50 years of life
Gjerde, Anna; Reisæter, Anna Varberg; Skrunes, Rannveig; Marti, Hans-Peter; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2020)Background and objectives: Previous studies have shown that individuals with low birth weight (LBW) or small for gestational age (SGA) have higher risk of kidney failure. This study investigates birth-related exposures and ... -
Intrauterine growth restriction, preterm birth and risk of end-stage renal disease during the first 50 years of life
Gjerde, Anna; Lillås, Bjørn Steinar; Marti, Hans-Peter; Reisæter, Anna Varberg; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2020)Background: Low birth weight (LBW) is associated with a higher risk of end-stage renal disease (ESRD). The relative impacts of absolute birth weight, birth weight in relation to gestational age and preterm birth are, ... -
Low birth weight and risk of progression to end stage renal disease in IgA nephropathy - A retrospective registry-based cohort study
Ruggajo, Paschal Joseph; Svarstad, Einar; Leh, Sabine Maria; Marti, Hans-Peter; Reisæter, Anna Varberg; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2016-04-19)Background: Low Birth Weight (LBW) is a surrogate for fetal undernutrition and is associated with impaired nephron development in utero. In this study, we investigate whether having been born LBW and/or small for gestational ... -
Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women
Lillås, Bjørn Steinar; Tøndel, Camilla; Assmus, Jörg; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2020)Background Low birthweight (LBW) has been shown to increase the risk of severe kidney disease. Studies have also shown associations between LBW and lower estimated glomerular filtration rate (GFR) in young adults. In this ... -
Measurement of renal functional response using iohexol clearance—a study of different outpatient procedures
Lillås, Bjørn Steinar; Tøndel, Camilla; Gjerde, Anna; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2019)Background: Glomerular filtration rate (GFR) increases after a heavy protein load; an increase termed renal functional response (RFR). Decreased RFR could be a marker of early kidney damage, but published methods are ... -
Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target
Eikrem, Øystein Solberg; Lillefosse, Bjørnar; Delaleu, Nicolas; Strauss, Philipp; Osman, Tarig Al-Hadi; Vikse, Bjørn Egil; Debiec, Hanna; Ronco, Pierre; Sekulic, Miroslav; Koch, Even Evjen; Furriol, Jessica; Leh, Sabine; Marti, Hans Peter (Journal article; Peer reviewed, 2023)Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, ... -
Prevalence and prognostic ability of the GOLD 2017 classification compared to the GOLD 2011 classification in a Norwegian COPD cohort
Le, Lan Ai Kieu; Johannessen, Ane; Hardie, Jon Andrew; Johansen, Odd Erik; Gulsvik, Amund; Vikse, Bjørn Egil; Bakke, Per S. (Peer reviewed; Journal article, 2019-07-23)Rationale: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 is based on an ABCD assessment tool of symptoms and exacerbation history and grade 1–4 of airflow limitation severity, facilitating ... -
Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats
Finne, Kenneth; Vethe, Heidrun; Skogstrand, Trude; Leh, Sabine Maria; Dahl, Tone Dolva; Tenstad, Olav; Berven, Frode S.; Reed, Rolf K.; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2014-08-16)Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ... -
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN
Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ... -
Renal Functional Response-Association With Birth Weight and Kidney Volume
Lillås, Bjørn Steinar Demma; Tøndel, Camilla; Melsom, Toralf; Eriksen, Bjørn Odvar; Marti, Hans Peter; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2023)Introduction: Renal functional response (RFR) is the acute increase in glomerular filtration rate (GFR) after a protein load. Low RFR is a marker of single nephron hyperfiltration. Low birth weight (LBW) is associated with ... -
Trends in Mortality Due to Myocardial Infarction, Stroke, and Pulmonary Embolism in Patients Receiving Dialysis
Ocak, Gurbey; Boenink, Rianne; Noordzij, Marlies; Bos, Willem Jan W.; Vikse, Bjørn Egil; Cases, Aleix; Kerschbaum, Julia; Helve, Jaakko; Nordio, Maurizio; Arici, Mustafa; Mercadal, Lucile; Wanner, Christoph; Palsson, Runolfur; Hommel, Kristine; De Meester, Johan; Kostopoulou, Myrto; Santamaria, Rafael; Rodrigo, Emilio; Rydell, Helena; Bell, Samira; Massy, Ziad A.; Jager, Kitty J.; Kramer, Anneke (Journal article; Peer reviewed, 2022)Importance: During the past decades, improvements in the prevention and management of myocardial infarction, stroke, and pulmonary embolism have led to a decline in cardiovascular mortality in the general population. ...