Browsing Department of Informatics by Author "Niazi, Adnan Muhammad"

Now showing items 1-3 of 3

    • Long-read single-molecule RNA structure sequencing using nanopore 

      Tilahun Bizuayehu, Teshome; Labun, Kornel; Jakubec, Martin; Jefimov, Kirill; Niazi, Adnan Muhammad; Valen, Eivind Dale (Journal article; Peer reviewed, 2022)
      RNA molecules can form secondary and tertiary structures that can regulate their localization and function. Using enzymatic or chemical probing together with high-throughput sequencing, secondary structure can be mapped ...

    • Nano3P-seq: transcriptome-wide analysis of gene expression and tail dynamics using end-capture nanopore cDNA sequencing 

      Begik, Oguzhan; Diensthuber, Gregor; Liu, Huanle; Delgado-Tejedor, Anna; Kontur, Cassandra; Niazi, Adnan Muhammad; Valen, Eivind; Giraldez, Antonio J.; Beaudoin, Jean-Denis; Mattick, John S.; Novoa, Eva Maria (Journal article; Peer reviewed, 2022)
      RNA polyadenylation plays a central role in RNA maturation, fate, and stability. In response to developmental cues, polyA tail lengths can vary, affecting the translation efficiency and stability of mRNAs. Here we develop ...

    • TailFindR: Alignment-free poly(A) length measurement for Oxford Nanopore RNA and DNA sequencing 

      Krause, Maximilian; Niazi, Adnan Muhammad; Labun, Kornel; Torres Cleuren, Yamila Nicole; Müller, Florian S; Valen, Eivind (Peer reviewed; Journal article, 2019-07-02)
      Polyadenylation at the 3′-end is a major regulator of messenger RNA and its length is known to affect nuclear export, stability, and translation, among others. Only recently have strategies emerged that allow for genome-wide ...