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dc.contributor.authorJohansson, Mattiasen_US
dc.contributor.authorAnouar, Fanidien_US
dc.contributor.authorMuller, David C.en_US
dc.contributor.authorBassett, Julie K.en_US
dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorVollset, Stein Emilen_US
dc.contributor.authorTravis, Ruth C.en_US
dc.contributor.authorPalli, Domenicoen_US
dc.contributor.authorMattiello, Amaliaen_US
dc.contributor.authorSieri, Sabinaen_US
dc.contributor.authorTrichopoulou, Antoniaen_US
dc.contributor.authorLagiou, Pagonaen_US
dc.contributor.authorTrichopoulos, Dimitriosen_US
dc.contributor.authorLjungberg, Börjeen_US
dc.contributor.authorHallmans, Göranen_US
dc.contributor.authorWeiderpass, Elisabeteen_US
dc.contributor.authorSkeie, Gurien_US
dc.contributor.authorGonzalez, Carlos A.en_US
dc.contributor.authorDorronsoro, Mirenen_US
dc.contributor.authorPeeters, Petra H.en_US
dc.contributor.authorBueno-de-Mesquita, H. B(as).en_US
dc.contributor.authorRos, Martine M.en_US
dc.contributor.authorRuault, Marie-Christine Boutronen_US
dc.contributor.authorFagherazzi, Guyen_US
dc.contributor.authorClavel, Françoiseen_US
dc.contributor.authorSanchez, Maria-Joseen_US
dc.contributor.authorGurrea, Aurelio Barricarteen_US
dc.contributor.authorNavarro, Carmenen_US
dc.contributor.authorQuirós, J. Ramónen_US
dc.contributor.authorOvervad, Kimen_US
dc.contributor.authorTjønneland, Anneen_US
dc.contributor.authorAleksandrova, Krassimiraen_US
dc.contributor.authorVineis, Paoloen_US
dc.contributor.authorGunter, Marc J.en_US
dc.contributor.authorKaaks, Rudolfen_US
dc.contributor.authorGiles, Grahamen_US
dc.contributor.authorRelton, Carolineen_US
dc.contributor.authorRiboli, Elioen_US
dc.contributor.authorBoeing, Heineren_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorBrennan, Paulen_US
dc.description.abstractBackground The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385 747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided. Results EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4th and 1st quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, Ptrend < .001. We found similar results after adjusting for potential confounders (adjusted Ptrend < .001). In survival analysis, the hazard ratio for all-cause mortality in RCC cases when comparing the 4th and 1st quartiles (HR4vs1) of vitamin B6 was 0.57 (95% CI = 0.37 to 0.87, Ptrend < .001). Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR4vs1 = 0.47, 95% CI = 0.23 to 0.99, Ptrend = .07) and all-cause mortality (HR4vs1 = 0.56, 95% CI = 0.27 to 1.17, Ptrend = .02). No association was evident for the other measured biomarkers. Conclusion Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution CC BY-NCeng
dc.titleCirculating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survivalen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 The Authors
dc.source.journalJournal of the National Cancer Institute
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716

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