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dc.contributor.authorStar, Bastiaaneng
dc.contributor.authorNederbragt, Alexander Johaneng
dc.contributor.authorJentoft, Sisseleng
dc.contributor.authorGrimholt, Unnieng
dc.contributor.authorMalmstrøm, Martineng
dc.contributor.authorGregers, Tone Fredsvikeng
dc.contributor.authorRounge, Trine Ballestadeng
dc.contributor.authorPaulsen, Jonaseng
dc.contributor.authorSolbakken, Monica Hongrøeng
dc.contributor.authorSharma, Animesheng
dc.contributor.authorWetten, Ola Frangeng
dc.contributor.authorLanzén, Anderseng
dc.contributor.authorWiner, Rogereng
dc.contributor.authorKnight, Jameseng
dc.contributor.authorVogel, Jan-Hinnerkeng
dc.contributor.authorAken, Bronweneng
dc.contributor.authorAndersen, Øivindeng
dc.contributor.authorLagesen, Karineng
dc.contributor.authorTooming-Klunderud, Aveeng
dc.contributor.authorEdvardsen, Rolfeng
dc.contributor.authorKirubakaran, G. Tinaeng
dc.contributor.authorEspelund, Marieng
dc.contributor.authorNepal, Chirageng
dc.contributor.authorPreviti, A. Christophereng
dc.contributor.authorKarlsen, Bård Oveeng
dc.contributor.authorMoum, Trulseng
dc.contributor.authorSkage, Morteneng
dc.contributor.authorBerg, Paul Ragnareng
dc.contributor.authorGjøen, Toreng
dc.contributor.authorKuhl, Heinereng
dc.contributor.authorThorsen, Jimeng
dc.contributor.authorMalde, Ketileng
dc.contributor.authorReinhardt, Richardeng
dc.contributor.authorDu, Leieng
dc.contributor.authorJohansen, Steinar Daaeeng
dc.contributor.authorSearle, Steveeng
dc.contributor.authorLien, Sigbjørneng
dc.contributor.authorNilsen, Frankeng
dc.contributor.authorJonassen, Ingeeng
dc.contributor.authorOmholt, Stig Weng
dc.contributor.authorStenseth, Nils Christianeng
dc.contributor.authorJakobsen, Kjetill Sigurdeng
dc.PublishedNature 2011, 477(7363):207-210eng
dc.description.abstractAtlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end libraries, and automated annotation identified 22,154 genes. The major histocompatibility complex (MHC) II is a conserved feature of the adaptive immune system of jawed vertebrates, but we show that Atlantic cod has lost the genes for MHC II, CD4 and invariant chain (Ii) that are essential for the function of this pathway. Nevertheless, Atlantic cod is not exceptionally susceptible to disease under natural conditions5. We find a highly expanded number of MHC I genes and a unique composition of its Toll-like receptor (TLR) families. This indicates how the Atlantic cod immune system has evolved compensatory mechanisms in both adaptive and innate immunity in the absence of MHC II. These observations affect fundamental assumptions about the evolution of the adaptive immune system and its components in vertebrates.en_US
dc.publisherNature Publishing Groupen_US
dc.rightsAttribution CC BY-NC-SAeng
dc.titleThe genome sequence of Atlantic cod reveals a unique immune systemen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 The Authorsen_US
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Genetics and genomics: 474

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