• Evolving mtDNA populations within cells 

      Johnston, Iain George; Burgstaller, Joerg (Peer reviewed; Journal article, 2019)
      Mitochondrial DNA (mtDNA) encodes vital respiratory machinery. Populations of mtDNA molecules exist in most eukaryotic cells, subject to replication, degradation, mutation, and other population processes. These processes ...
    • Mitochondrial network state scales mtDNA genetic dynamics 

      Aryaman, Juvid; Bowles, Charlotte; Jones, Nick; Johnston, Iain George (Peer reviewed; Journal article, 2019)
      Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. mtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion ...
    • Model selection and parameter estimation for root architecture models using likelihood-free inference 

      Ziegler, Clare; Dyson, Rosemary; Johnston, Iain George (Peer reviewed; Journal article, 2019)
      Plant root systems play vital roles in the biosphere, environment and agriculture, but the quantitative principles governing their growth and architecture remain poorly understood. The ‘forward problem’ of what root forms ...
    • Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data 

      Johnston, Iain George; Hoffmann, Till; Greenbury, Sam; Cominetti, Ornella; Jallow, Muminatou; Kwiatkowski, Dominic; Barahona, Mauricio; Jones, Nick; Casals-Pascual, Climent (Peer reviewed; Journal article, 2019)
      More than 400,000 deaths from severe malaria (SM) are reported every year, mainly in African children. The diversity of clinical presentations associated with SM indicates important differences in disease pathogenesis that ...
    • Varied mechanisms and models for the varying mitochondrial bottleneck 

      Johnston, Iain George (Peer reviewed; Journal article, 2019-11-20)
      Mitochondrial DNA (mtDNA) molecules exist in populations within cells, and may carry mutations. Different cells within an organism, and organisms within a family, may have different proportions of mutant mtDNA in these ...