Browsing Department of Mathematics by Journals "Environmental Science and Technology"

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New Conceptual Toxicokinetic Model to Assess Synergistic Mixture Effects between the Aromatic Hydrocarbon β-Naphthoflavone and the Azole Nocodazole on the CYP1A Biomarker in a Fish Cell Line

Fallahi, Shirin; Mlnaříková, Marie; Alvord, Charlotte; Alendal, Guttorm; Frøysa, Håvard G; Lundh, Thorbjörn; Celander, Malin C. (Journal article; Peer reviewed, 2020)

Toxicokinetic interactions with catabolic cytochrome P450 (CYP) enzymes can inhibit chemical elimination pathways and cause synergistic mixture effects. We have created a mathematical bottom-up model for a synergistic ...