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dc.contributor.authorRamokolo, Vundlien_US
dc.contributor.authorLombard, Carlen_US
dc.contributor.authorChhagan, Meera Kursonen_US
dc.contributor.authorEngebretsen, Ingunn Marie S.en_US
dc.contributor.authorDoherty, Tanyaen_US
dc.contributor.authorGoga, Ameena E.en_US
dc.contributor.authorFadnes, Lars Thoreen_US
dc.contributor.authorZembe, Wangaen_US
dc.contributor.authorJackson, Debra J.en_US
dc.contributor.authorVan den Broeck, Janen_US
dc.PublishedInternational Breastfeeding Journal 2015, 10:14eng
dc.description.abstractBackground South Africa has the highest prevalence of overweight/obesity in Sub-Saharan Africa. Assessing the effect of modifiable factors such as early infant feeding on growth velocity and overweight/obesity is therefore important. This paper aimed to assess the effect of infant feeding in the transitional period (12 weeks) on 12–24 week growth velocity amongst HIV unexposed children using WHO growth velocity standards and on the age and sex adjusted body mass index (BMI) Z-score distribution at 2 years. Methods Data were from 3 sites in South Africa participating in the PROMISE-EBF trial. We calculated growth velocity Z-scores using the WHO growth standards and assessed feeding practices using 24-hour and 7-day recall data. We used quantile regression to study the associations between 12 week infant feeding and 12–24 week weight velocity (WVZ) with BMI-for-age Z-score at 2 years. We included the internal sample quantiles (70th and 90th centiles) that approximated the reference cut-offs of +2 (corresponding to overweight) and +3 (corresponding to obesity) of the 2 year BMI-for-age Z-scores. Results At the 2-year visit, 641 children were analysed (median age 22 months, IQR: 17–26 months). Thirty percent were overweight while 8.7% were obese. Children not breastfed at 12 weeks had higher 12–24 week mean WVZ and were more overweight and obese at 2 years. In the quantile regression, children not breastfed at 12 weeks had a 0.37 (95% CI 0.07, 0.66) increment in BMI-for-age Z-score at the 50th sample quantile compared to breast-fed children. This difference in BMI-for-age Z-score increased to 0.46 (95% CI 0.18, 0.74) at the 70th quantile and 0.68 (95% CI 0.41, 0.94) at the 90th quantile . The 12–24 week WVZ had a uniform independent effect across the same quantiles. Conclusions This study demonstrates that the first 6 months of life is a critical period in the development of childhood overweight and obesity. Interventions targeted at modifiable factors such as early infant feeding practices may reduce the risks of rapid weight gain and subsequent childhood overweight/obesity.en_US
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="" target="_blank">Growth of HIV-exposed and HIV–unexposed children in South Africa. Anthropometric nutritional status and growth rates</a>
dc.rightsAttribution CC BYeng
dc.titleEffects of early feeding on growth velocity and overweight/obesity in a cohort of HIV unexposed South African infants and childrenen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 Ramokolo et al.; licensee BioMed Central
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803
dc.subject.nsiVDP::Medisinske Fag: 700en_US

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