Browsing Department of Biological and Medical Psychology by Author "Mann, Matthias"

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Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation

Trentini, Débora Broch; Pecoraro, Matteo; Tiwary, Shivani; Cox, Heinz Jürgen; Mann, Matthias; Hipp, Mark S.; Hartl, F. Ulrich (Journal article; Peer reviewed, 2020)

Pathogens and tumors are detected by the immune system through the display of intracellular peptides on MHC-I complexes. These peptides are generated by the ubiquitin−proteasome system preferentially from newly synthesized ...