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Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine
(Journal article; Peer reviewed, 2021)Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ... -
The novel reconsidered: Emotions and anti-realism in mid-19th-century Scandinavian literature
(Journal article; Peer reviewed, 2021)The aim of the present article is to investigate the novel as remediation of nationalist pedagogy: how was the pedagogical, nationalist project charged with emotions? How did elements from non-realist genres make emotions ... -
A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
(Journal article; Peer reviewed, 2023)Background: The genetic disease architecture of Inuit includes a large number of common high-impact variants. Identification of such variants contributes to our understanding of the genetic aetiology of diseases and improves ... -
Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
(Journal article; Peer reviewed, 2022)Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ... -
Nowcasting COVID-19 incidence indicators during the Italian first outbreak
(Journal article; Peer reviewed, 2021)A novel parametric regression model is proposed to fit incidence data typically collected during epidemics. The proposal is motivated by real-time monitoring and short-term forecasting of the main epidemiological indicators ... -
NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition
(Journal article; Peer reviewed, 2022)The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ... -
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease
(Journal article; Peer reviewed, 2023)Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains ... -
NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study
(Journal article; Peer reviewed, 2021-09-07)Objective: Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson’s disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID ... -
Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission
(Journal article; Peer reviewed, 2020)Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ... -
Nuclear modification factor of light neutral-meson spectra up to high transverse momentum in p–Pb collisions at √sNN = 8.16 TeV
(Journal article; Peer reviewed, 2022)Neutral pion (π0) and η meson production cross sections were measured up to unprecedentedly high transverse momenta (pT) in p–Pb collisions at √sNN = 8.16 TeV. The mesons were reconstructed via their two-photon decay channel ... -
Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins
(Journal article; Peer reviewed, 2021)Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin ... -
The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth
(Journal article; Peer reviewed, 2022)Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500–1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells. ... -
Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells
(Journal article; Peer reviewed, 2021)The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α and p110β are ubiquitously expressed but differently targeted in tumours. In cancer, PIK3CB (encoding p110β) is seldom mutated compared with PIK3CA ... -
Nucleated red blood cells explain most of the association between DNA methylation and gestational age
(Journal article; Peer reviewed, 2023)Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ... -
Nude heritage selfies as a visual practice
(Journal article; Peer reviewed, 2022)In the mid-2010s, the media reported a series of disturbances at heritage sites caused by visitors taking nude self-photographs or selfies. In this article, nude selfies are analysed as a visual practice, and it is discussed ... -
Nudging Healthy Choices in Food Search Through Visual Attractiveness
(Journal article; Peer reviewed, 2021)Recipe websites are becoming increasingly popular to support people in their home cooking. However, most of these websites prioritize popular recipes, which tend to be unhealthy. Drawing upon research on visual biases and ... -
Nudging Towards Health in a Conversational Food Recommender System Using Multi-Modal Interactions and Nutrition Labels
(Chapter, 2022)Humans engage with other humans and their surroundings through various modalities, most notably speech, sight, and touch. In a conversation, all these inputs provide an overview of how another person is feeling. When ... -
Nudging Towards Health? Examining the Merits of Nutrition Labels and Personalization in a Recipe Recommender System
(Chapter, 2022)Food recommender systems show personalized recipes to users based on content liked previously. Despite their potential, often recommended (popular) recipes in previous studies have turned out to be unhealthy, negatively ... -
Nullpunktet?
(Chapter, 2022)How does art produce subjectivity, and does art always work for a better production of subjectivity? With an outset in an ethnographic study and participatory observation of youth encountering practices of contemporary art ... -
A number theoretic view on binary shift registers
(Journal article; Peer reviewed, 2022)We describe a number theoretic view on binary shift registers. We illustrate this approach on some basic shift registers by revisiting known and obtaining new results, which we prove using tools from basic number theory, ...