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Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease
(Journal article; Peer reviewed, 2021)All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ... -
Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ... -
Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin
(Journal article; Peer reviewed, 2023)Secretomes of mesenchymal stromal cells (MSCs) are emerging as a novel growth factor (GF)-based strategy for periodontal and bone regeneration. The objective of this study was to compare the secretome of human bone marrow ... -
Proteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: A pilot study from Zanzibar, Tanzania
(Journal article; Peer reviewed, 2023)This study aimed at exploring the proteomic profile of PBMCs to predict treatment response in pulmonary tuberculosis (PTB). This was a pilot study conducted among 8 adult patients from Zanzibar, Tanzania with confirmed ... -
Proteomic Analysis of Zebrafish Protein Recoding via mRNA Editing by ADAR Enzymes
(Journal article; Peer reviewed, 2022)RNA editing by adenosine deaminases of the ADAR family can lead to protein recoding, since inosine formed from adenosine in mRNA is complementary to cytosine; the resulting codon editing might introduce amino acid substitutions ... -
Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease
(Journal article; Peer reviewed, 2023)Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ... -
Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells
(Journal article; Peer reviewed, 2021)Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ... -
Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN
(Journal article; Peer reviewed, 2022-03-24)Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ... -
Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
(Journal article; Peer reviewed, 2021)All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and ... -
Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)
(Journal article; Peer reviewed, 2020)The aim of the present study was to investigate effects of defined mixtures of polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× = H) ... -
A proteomics sample metadata representation for multiomics integration and big data analysis
(Journal article; Peer reviewed, 2021)The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding ... -
Protocol for a multicentre, parallelgroup, open-label randomised controlled trial comparing ferric carboxymaltose with the standard of care in anaemic Malawian pregnant women: the REVAMP trial
(Journal article; Peer reviewed, 2021)Introduction Anaemia in pregnancy remains a critical global health problem, affecting 46% of pregnant women in Africa and 49% in Asia. Oral iron therapy requires extended adherence to achieve correction of anaemia and ... -
Protocol for a systematic review and meta-analysis on the associations between shift work and sickness absence
(Journal article; Peer reviewed, 2022)Background Shift work, i.e., non-standard work hours, has been associated with both short- and long-term sickness absence. However, findings are inconsistent and inconclusive. Thus far, no comprehensive meta-analytic ... -
Protocol for data extraction: how realworld data have been used in the National Institute for Health and Care Excellence appraisals of cancer therapy
(Journal article; Peer reviewed, 2022)Introduction Due to the limitations of relying on randomised controlled trials, the potential benefits of real-world data (RWD) in enriching evidence for health technology assessment (HTA) are highlighted. Despite increased ... -
Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors
(Journal article; Peer reviewed, 2021)Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from ... -
A Protocorinthian aryballos with a myth scene from Tegea
(Journal article; Peer reviewed, 2020)During the preparation of the new exhibition in the Museum of Tegea it was discovered that one composed fragment from a Protocorinthian aryballos with a complicated, figured representation, found during the excavations of ... -
Proton acceleration in thermonuclear nova explosions revealed by gamma rays
(Journal article; Peer reviewed, 2022)Classical novae are cataclysmic binary star systems in which the matter of a companion star is accreted on a white dwarf1,2. Accumulation of hydrogen in a layer eventually causes a thermonuclear explosion on the surface ... -
Protracted late Neoproterozic – early Palaeozoic deformation and cooling history of Sør Rondane, East Antarctica, from 40Ar/39Ar and U–Pb geochronology
(Journal article; Peer reviewed, 2020)40Ar/39Ar and U–Pb data from five structural domains constrain the late Neoproterozoic – early Palaeozoic tectonothermal history of the eastern part of the East African–Antarctic Orogen in Sør Rondane. A total of 27 new ... -
Provenance and transport of supraglacial debris revealed by variations in debris geochemistry on Khumbu Glacier, Nepal Himalaya
(Journal article; Peer reviewed, 2023)The origin of supraglacial debris covers is often conceptualised as the formation of a surface lag by melt-out of englacial debris from slow-moving ice, where complexity arises from feedback between debris thickness and ... -
Providers’ Experiences with Delivering School‑Based Targeted Prevention for Adolescents with Anxiety Symptoms: A Qualitative Study
(Journal article; Peer reviewed, 2020)The school setting is important for delivering targeted prevention to adolescents with anxiety. However, schools may not have available providers with training or experience in delivering evidence-based interventions, e.g., ...