• Actions on sustainable food production and consumption for the post-2020 global biodiversity framework 

      Delabre, Izabela; Rodriguez, Lily O.; Smallwood, Joanna Miller; Scharlemann, Jörn P.W.; Alcamo, Joseph; Antonarakis, Alexander S.; Rowhani, Pedram; Hazell, Richard J.; Aksnes, Dag Lorents; Balvanera, Patricia; Lundquist, Carolyn J.; Gresham, Charlotte; Alexander, Anthony E.; Stenseth, Nils Christian (Journal article; Peer reviewed, 2021)
      Current food production and consumption trends are inconsistent with the Convention on Biological Diversity’s 2050 vision of living in harmony with nature. Here, we examine how, and under what conditions, the post-2020 ...
    • Atmospheric circulation over Europe during the Younger Dryas 

      Rea, B.R.; Pellitero, R.; Spagnolo, M.; Hughes, P.D.; Ivy-Ochs, S.; Renssen, Hans; Ribolini, A.; Bakke, Jostein; Lukas, S.; Braithwaite, R.J. (Journal article; Peer reviewed, 2020)
      The Younger Dryas (YD) was a period of rapid climate cooling that occurred at the end of the last glaciation. Here, we present the first palaeoglacier-derived reconstruction of YD precipitation across Europe, determined ...
    • Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics 

      Lechuga-Vieco, Ana Victoria; Latorre-Pellicer, Ana; Johnston, Iain; Prota, Gennaro; Gileadi, Uzi; Justo-Méndez, Raquel; Acín-Pérez, Rebeca; Martínez-De-Mena, Raquel; Fernández-Toro, Jose María; Jimenez-Blasco, Daniel; Mora, Alfonso; Nicolás-Ávila, Jose A.; Santiago, Demetrio J.; Priori, Silvia G.; Bolaños, Juan Pedro; Sabio, Guadalupe; Criado, Luis Miguel; Ruíz-Cabello, Jesús; Cerundolo, Vincenzo; Jones, Nick S.; Enríquez, Jose Antonio (Journal article; Peer reviewed, 2020)
      Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic ...
    • Chlamydial contribution to anaerobic metabolism during eukaryotic evolution 

      Stairs, Courtney W.; Sharamshi, Jennah E.; Tamarit, Daniel; Eme, Laura; Jørgensen, Steffen Leth; Spang, Anja; Ettema, Thijs J.G. (Journal article; Peer reviewed, 2020)
      The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on ...
    • Early human impacts and ecosystem reorganization in southern-central Africa 

      Thompson, Jessica; Wright, David K.; Ivory, Sarah J; Choi, Jeong-Heon; Nightingale, Sheila; Mackay, Alex; Schilt, Flora; Otarola-Castillo, Erik; Mercader, Julio; Forman, Steven L.; Pietsch, Timothy; Cohen, Andrew S.; Arrowsmith, J. Ramon; Welling, Menno; Davis, Jacob; Schiery, Benjamin; Kaliba, Potiphar; Malijani, Oris; Blome, Margaret W.; O'Driscoll, Corey A.; Mentzer, Susan M.; Miller, Christopher E.; Heo, Seoyoung; Choi, Jungyu; Tembo, Joseph; Mapemba, Fredrick; Simengwa, Davie; Gomani-Chindebvu, Elizabeth (Journal article; Peer reviewed, 2021-05-05)
      Modern Homo sapiens engage in substantial ecosystem modification, but it is difficult to detect the origins or early consequences of these behaviors. Archaeological, geochronological, geomorphological, and paleoenvironmental ...
    • An ecological niche shift for Neanderthal populations in Western Europe 70,000 years ago 

      Banks, William E.; Moncel, Marie-Helene; Raynal, J.P.; Cobos, MC; Romero-Alvarez, D; woillez, M-N; Faivre, Jean-Philippe; Gravina, Brad; d'Errico, Francesco; Locht, Jean-Luc; Santos, Frédéric (Journal article; Peer reviewed, 2021)
      Middle Paleolithic Neanderthal populations occupied Eurasia for at least 250,000 years prior to the arrival of anatomically modern humans. While a considerable body of archaeological research has focused on Neanderthal ...
    • Evolution of vegetation and climate variability on the Tibetan Plateau over the past 1.74 million years 

      Zhao, Yan; Tzedakis, P. Chronis; Li, Quan; Qin, Feng; Cui, Qiaoyu; Liang, Chen; Birks, Harry John Betteley; Liu, Yaoliang; Zhang, Zhiyong; Ge, Junyi; Zhao, Hui; Felde, Vivian Astrup; Deng, Chenglong; Cai, Maotang; Li, Huan; Ren, Weihe; Wei, Haicheng; Yang, Hanfei; Zhang, Jiawu; Yu, Zicheng; Guo, Zhengtang (Journal article; Peer reviewed, 2020)
      The Tibetan Plateau exerts a major influence on Asian climate, but its long-term environmental history remains largely unknown. We present a detailed record of vegetation and climate changes over the past 1.74 million years ...
    • GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production 

      Mahootchi, Elaheh; Homaei, Selina Cannon; Kleppe, Rune; Winge, Ingeborg; Hegvik, Tor-Arne; Perez, Roberto Megias; Totland, Christian; Mogavero, Floriana; Baumann, Anne; Glennon, Jeffrey Colm; Miletic, Hrvoje; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2020)
      Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This ...
    • How is a turbidite actually deposited? 

      Ge, Zhiyuan; Nemec, Wojciech; Vellinga, Age; Gawthorpe, Robert Leslie (Journal article; Peer reviewed, 2022)
      The deposition of a classic turbidite by a surge-type turbidity current, as envisaged by conceptual models, is widely considered a discrete event of continuous sediment accumulation at a falling rate by the gradually waning ...
    • Human footprints provide snapshot of last interglacial ecology in the Arabian interior 

      Stewart, Mathew; Clark-Wilson, Richard; Breeze, Paul S; Janulis, Klint; Candy, Ian; Armitage, Simon James; Ryves, David B.; Louys, Julien; Duval, Mathieu; Price, Gilbert J; Cuthbertson, Patrick; Bernal, Marco A.; Drake, Nick A; Alsharekh, Abdullah; Zahrani, Badr; Al-Omari, Abdulaziz; Roberts, Patrick; Groucutt, Huw S.; Petraglia, Michael D. (Journal article; Peer reviewed, 2020)
      The nature of human dispersals out of Africa has remained elusive because of the poor resolution of paleoecological data in direct association with remains of the earliest non-African people. Here, we report hominin and ...
    • Mechanism of actin N-terminal acetylation 

      Rebowski, Grzegorz; Boczkowska, Malgorzata; Drazic, Adrian; Ree, Rasmus Moen; Goris, Marianne; Arnesen, Thomas; Dominguez, Roberto (Journal article; Peer reviewed, 2020)
      About 80% of human proteins are amino-terminally acetylated (Nt-acetylated) by one of seven Nt-acetyltransferases (NATs). Actin, the most abundant protein in the cytoplasm, has its own dedicated NAT, NAA80, which acts ...
    • North Atlantic Oscillation in winter is largely insensitive to autumn Barents-Kara sea ice variability 

      Siew, Yu Feng; Li, Camille; Ting, Mingfang; Sobolowski, Stefan Pieter; Wu, Yutian; Chen, Xiaodan (Journal article; Peer reviewed, 2021)
      Arctic sea ice extent in autumn is significantly correlated with the winter North Atlantic Oscillation (NAO) in the satellite era. However, questions about the robustness and reproducibility of the relationship persist. ...
    • Sedimentary ancient DNA shows terrestrial plant richness continuously increased over the Holocene in northern Fennoscandia 

      Rijal, Dilli Prasad; Heintzman, Peter D.; Lammers, Youri; Yoccoz, Nigel; Lorberau, Kelsey; Pitelkova, Iva; Goslar, Tomasz; Murguzur, Francisco Javier Ancin; Salonen, J. Sakari; Helmens, Karin F.; Bakke, Jostein; Edwards, Mary E.; Alm, Torbjørn; Bråthen, Kari Anne; Brown, Antony; Alsos, Inger Greve (Journal article; Peer reviewed, 2021)
      The effects of climate change on species richness are debated but can be informed by the past. Here, we generated a sedimentary ancient DNA dataset covering 10 lakes and applied novel methods for data harmonization. We ...
    • Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal 

      Svensson, Mattias N.D.; Zoccheddu, Martina; Yang, Shen; Nygaard, Gyrid; Secchi, Christian; Doody, Karen M.; Slowikowski, Kamil; Mizoguchi, Fumitaka; Humby, Frances; Hands, Rebecca; Santelli, Eugenio; Sacchetti, Cristiano; Wakabayashi, Kuninobu; Wu, Dennis J.; Barback, Christopher; Ai, Rizi; Wang, Wei; Sims, Gary P.; Mydel, Piotr Mateusz; Kasama, Tsuyoshi; Boyle, David L.; Galimi, Francesco; Vera, David; Tremblay, Michel L.; Raychaudhuri, Soumya; Brenner, Michael B.; Firestein, Gary S.; Pitzalis, Costantino; Ekwall, Anna-Karin H.; Stanford, Stephanie M.; Bottini, Nunzio (Journal article; Peer reviewed, 2020)
      Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted ...