Show simple item record

dc.contributor.authorGoncearenco, Alexander
dc.contributor.authorMitternacht, Simon
dc.contributor.authorYong, Taipang
dc.contributor.authorEisenhaber, Birgit
dc.contributor.authorEisenhaber, Frank
dc.contributor.authorBerezovsky, Igor
dc.PublishedNucleic Acids Research 2013, 41(W1):W266-W272eng
dc.description.abstractThe SPACER server provides an interactive framework for exploring allosteric communication in proteins with different sizes, degrees of oligomerization and function. SPACER uses recently developed theoretical concepts based on the thermodynamic view of allostery. It proposes easily tractable and meaningful measures that allow users to analyze the effect of ligand binding on the intrinsic protein dynamics. The server shows potential allosteric sites and allows users to explore communication between the regulatory and functional sites. It is possible to explore, for instance, potential effector binding sites in a given structure as targets for allosteric drugs. As input, the server only requires a single structure. The server is freely available at
dc.publisherOxford University Press (OUP)eng
dc.rightsAttribution CC BY 3.0eng
dc.titleSPACER: server for predicting allosteric communication and effects of regulationeng
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2013eng
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Bioinformatikk: 475
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Bioinformatics: 475
dc.subject.nsiVDP::Teknologi: 500nob

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY 3.0
Except where otherwise noted, this item's license is described as Attribution CC BY 3.0