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dc.contributor.authorJoubert, Bonnie Ren_US
dc.contributor.authorDen Dekker, Herman Ten_US
dc.contributor.authorFelix, Janine Fen_US
dc.contributor.authorBohlin, Jonen_US
dc.contributor.authorLigthart, Symenen_US
dc.contributor.authorBeckett, Emmaen_US
dc.contributor.authorTiemeier, Henningen_US
dc.contributor.authorvan Meurs, Joyce Ben_US
dc.contributor.authorUitterlinden, Andre Gen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorHåberg, Siri Eldeviken_US
dc.contributor.authorReese, Sarah Een_US
dc.contributor.authorPeters, Marjolein Jen_US
dc.contributor.authorKulle Andreassen, Bettinaen_US
dc.contributor.authorSteegers, Eric A Pen_US
dc.contributor.authorNilsen, Roy Miodinien_US
dc.contributor.authorVollset, Stein Emilen_US
dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorFranco, Oscar Hen_US
dc.contributor.authorDehghan, Abbasen_US
dc.contributor.authorDe Jongste, Johan Cen_US
dc.contributor.authorWu, Michael Cen_US
dc.contributor.authorWang, Tianyuanen_US
dc.contributor.authorPeddada, Shyamal Den_US
dc.contributor.authorJaddoe, Vincent W Ven_US
dc.contributor.authorNystad, Wencheen_US
dc.contributor.authorDuijts, Liesbethen_US
dc.contributor.authorLondon, Stephanie Jen_US
dc.PublishedNature Communications 2016, 7:10577eng
dc.description.abstractFolate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. We examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina’s HumanMethyl450 Beadchip in 1,988 newborns from two European cohorts. Here we report the combined covariate-adjusted results using meta-analysis and employ pathway and gene expression analyses. Four-hundred forty-three CpGs (320 genes) are significantly associated with maternal plasma folate levels during pregnancy (false discovery rate 5%); 48 are significant after Bonferroni correction. Most genes are not known for folate biology, including APC2, GRM8, SLC16A12, OPCML, PRPH, LHX1, KLK4 and PRSS21. Some relate to birth defects other than neural tube defects, neurological functions or varied aspects of embryonic development. These findings may inform how maternal folate impacts the developing epigenome and health outcomes in offspring.en_US
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.titleMaternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newbornsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Authors

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