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Microbiota that affect risk for shigellosis in children in low-income countries

Lindsay, Brianna; Oundo, Joseph O.; Hossain, Mohammad Anowar; Antonio, Martin; Tamboura, Boubou; Walker, Alan W.; Paulson, Joseph N.; Parkhill, Julian; Omore, Richard; Faruque, Abu Syed Golam; Das, Suman Kumar; Ikumapayi, Usman Nurudeen; Adeyemi, Mitchell; Sanogo, Doh; Saha, Debasish; Sow, Samba O.; Farag, Tamer H.; Nasrin, Dilruba; Li, Shan; Panchalingam, Sandra; Levine, Myron M.; Kotloff, Karen; Magder, Laurence S.; Hungerford, Laura L.; Sommerfelt, Halvor; Pop, Mihai; Nataro, James Paul; Stine, Oscar Colin
Peer reviewed, Journal article
Published version
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Åpne
14-0795.pdf (818.7Kb)
cristin-1249363.xml (28.87Kb)
Permanent lenke
https://hdl.handle.net/1956/12466
Utgivelsesdato
2015
Metadata
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Samlinger
  • Department of Global Public Health and Primary Care [2533]
Originalversjon
https://doi.org/10.3201/eid2102.140795
Sammendrag
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.
Utgiver
Centers for Disease Control and Prevention
Opphavsrett
Emerging Infectious Diseases is published by the Centers for Disease Control and Prevention, a U.S. Government agency. Therefore, materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs are in the public domain and can be reprinted or used without permission with proper citation.

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