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Cytotoxicity of eluates from denture base materials

Nguyen, Long Giang
Master thesis
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URI
https://hdl.handle.net/1956/12873
Date
2015-01-26
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  • Department of Clinical Dentistry [240]
Abstract
Background: Some patients do not tolerate polymethylmethacrylate-based (PMMA) dentures. Polyamide as an alternative to PMMA has, however, not been well documented regarding to biocompatibility and cytotoxicity. Aim: The purpose of this study was to determine in vitro the effect of eluates from polyamide denture base resin on apoptosis and necrosis. Materials and methods: Eluates from three auto-polymerized PMMA, an auto-polymerized vinyl polysiloxane, a heat-polymerized PMMA and two polyamide based resin were investigated. The characteristics of apoptosis and necrosis were evaluated by flow cytometry. Results: The results showed no statistical differences in cell death among the materials. Conclusion: No definitive conclusion could be drawn based on the results of this study. Further studies are needed in order to make a thorough evaluation of the biocompatibility of polyamide-based denture base materials.
 
Bakgrunn: Noen pasienter tolererer ikke polymetylmetakrylat baserte (PMMA) tannprotester. Polyamid er brukt som et alternativ til PMMA, men det mangler fortsatt dokumentasjon med hensyn til biokompatibilitet og cytotoksisitet. Mål: Hensikten med denne studien var å bestemme, in vitro, effekten av eluater fra polyamid protesebasis resin på apoptose og nekrose. Materialer og metoder: Eluater fra tre autopolymeriserte PMMA, en autopolymerisert vinyl polysiloksan, en varm polymerisert PMMA og to polyamid-basert resiner ble undersøkt. Kjennetegnene for apoptose og nekrose ble evaluert ved flow cytometri. Resultater: Resultatene viste ingen signifikant forskjell i celledød mellom de ulike materialene. Konklusjon: Basert på resultatene av denne studien kan ingen endelig konklusjon trekkes. Videre forsøk er nødvending for å kunne kartlegge biokompatibiliteten til polyamid-basert protese materialer.
 
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The University of Bergen

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