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dc.contributor.authorRamokolo, Vundlien_US
dc.contributor.authorGoga, Ameena E.en_US
dc.contributor.authorLombard, Carlen_US
dc.contributor.authorDoherty, Tanyaen_US
dc.contributor.authorJackson, Debra J.en_US
dc.contributor.authorEngebretsen, Ingunn Marie S.en_US
dc.date.accessioned2017-12-11T11:17:07Z
dc.date.available2017-12-11T11:17:07Z
dc.date.issued2017-10
dc.identifier.issn2328-8957
dc.identifier.urihttps://hdl.handle.net/1956/16995
dc.description.abstractBackground. Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant in utero HIV and ART exposure on preterm delivery (PTD), low birth weight (LBW), small for gestational age (SGA), and underweight for age (UFA) at 6 weeks. Methods. We surveyed 6179 HIV-unexposed-uninfected (HUU) and 2599 HIV-exposed-uninfected (HEU) infants. HEU infants were stratified into 3 groups: ART, Zidovudine alone, and no antiretrovirals (None). The ART group was further stratified to explore pre- or postconception exposure. Multivariable logistic regression evaluated effects of HIV and ARV exposure on the outcomes. Results. We found higher odds of PTD, LBW, SGA, and UFA in HEU than HUU infants. HEU in the None group (adjusted odds ratio [AOR], 1.9; 95% confidence interval [CI], 1.2–3.0) or those whose mothers initiated ART preconception (AOR, 1.7; 95% CI, 1.1–2.5) had almost twice the odds of PTD than infants whose mothers started ART postconception, but no increased odds for other outcomes. Conclusions. There was an association between preconception ART and PTD. As ART access increases, pregnancy registers or similar surveillance should be in place to monitor outcomes to inform future policy.en_US
dc.language.isoengeng
dc.publisherOxford University Presseng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/16996" target="_blank">Growth of HIV-exposed and HIV–unexposed children in South Africa. Anthropometric nutritional status and growth rates</a>
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectantiretroviral therapyeng
dc.subjectbirth outcomeeng
dc.subjectHIVeng
dc.subjectSouth Africaeng
dc.titleIn Utero ART Exposure and Birth and Early Growth Outcomes Among HIV-Exposed Uninfected Infants Attending Immunization Services: Results From National PMTCT Surveillance, South Africaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Author(s)
dc.source.articlenumberofx187
dc.identifier.doihttps://doi.org/10.1093/ofid/ofx187
dc.source.journalOpen Forum Infectious Diseases
dc.source.404
dc.source.144


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