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dc.contributor.authorSomé, Ericen_US
dc.contributor.authorEngebretsen, Ingunn Marie S.en_US
dc.contributor.authorNagot, Nicolasen_US
dc.contributor.authorMeda, Nicolas Yen_US
dc.contributor.authorVallo, Roselyneen_US
dc.contributor.authorKankasa, Chipepoen_US
dc.contributor.authorTumwine, James Ken_US
dc.contributor.authorSingata, Mandisaen_US
dc.contributor.authorHofmeyr, Justus Gen_US
dc.contributor.authorVan De Perre, Philippeen_US
dc.contributor.authorTylleskär, Thorkilden_US
dc.contributor.authorMarechal, Valerieen_US
dc.contributor.authorNeveu, Dorineen_US
dc.contributor.authorFoulongne, Vincenten_US
dc.contributor.authorSegondy, Michelen_US
dc.contributor.authorSchaub, Roxanneen_US
dc.contributor.authorBlanche, Stephaneen_US
dc.contributor.authorTreluyer, Jean-Marcen_US
dc.contributor.authorHirt, Deborahen_US
dc.contributor.authorKaramagi, Charlesen_US
dc.contributor.authorMusoke, Philippaen_US
dc.contributor.authorNdeezi, Graceen_US
dc.contributor.authorMugaba, Proscovia Men_US
dc.contributor.authorKwagala, Maryen_US
dc.contributor.authorMurungi, Joanen_US
dc.contributor.authorMuweesi, Hawa Nabuumaen_US
dc.contributor.authorNinsiima, Evelynen_US
dc.contributor.authorBaryeija, Simonen_US
dc.contributor.authorOuedraogo, Rasmataen_US
dc.contributor.authorYe, Diarraen_US
dc.contributor.authorTraore, Hugues Aen_US
dc.contributor.authorNadembega, Christelleen_US
dc.contributor.authorKonate, Justinen_US
dc.contributor.authorZongo, Arseneen_US
dc.contributor.authorOuedraogo, Abassen_US
dc.contributor.authorNeboua, Desireen_US
dc.contributor.authorBelemvire, Aissatouen_US
dc.contributor.authorBambara, Armelen_US
dc.contributor.authorBoncoungou, Justineen_US
dc.contributor.authorZoungrana, Danielleen_US
dc.contributor.authorNikodem, Cherylen_US
dc.contributor.authorHarper, Kimen_US
dc.contributor.authorJackson, Debraen_US
dc.contributor.authorSanders, Daviden_US
dc.contributor.authorSunday, Amween_US
dc.contributor.authorOkegbe-Eze, Collinsen_US
dc.contributor.authorWilliams, Xoliswaen_US
dc.contributor.authorMshweshwe, Nolundien_US
dc.contributor.authorHenge, Vatiswaen_US
dc.contributor.authorGomba, Fikiswaen_US
dc.contributor.authorNikodem, Ladaen_US
dc.contributor.authorKhondowe, Oswellen_US
dc.contributor.authorMwiya, Mwiyaen_US
dc.contributor.authorLusaka, Mildreeden_US
dc.contributor.authorChizyuka, Maryen_US
dc.contributor.authorPhiri, Maryen_US
dc.contributor.authorImakando, Billiesen_US
dc.contributor.authorMusaku, Mwenechanyaen_US
dc.contributor.authorKapasa, Monicaen_US
dc.contributor.authorRutagwera, Daviden_US
dc.contributor.authorClement, Ngondween_US
dc.contributor.authorMwaba, Hilton Mwilaen_US
dc.contributor.authorMatoba, Japheten_US
dc.contributor.authorMwaba, Hiltonen_US
dc.contributor.authorSiumita, Chafyeen_US
dc.contributor.authorChola, Kataien_US
dc.contributor.authorMwamutanda, Patriciaen_US
dc.PublishedSomé E, Engebretsen IMS, Nagot N, Meda, Vallo R, Kankasa C, Tumwine JK, Singata M, Hofmeyr, Van De Perre P, Tylleskär T, Marechal V, Neveu D, Foulongne, Segondy, Schaub, Blanche S, Treluyer, Hirt, Karamagi C, Musoke P, Ndeezi G, Mugaba, Kwagala M, Murungi, Muweesi, Ninsiima, Baryeija, Ouedraogo, Ye, Traore, Nadembega, Konate, Zongo, Ouedraogo, Neboua, Belemvire, Bambara, Boncoungou, Zoungrana, Nikodem C, Harper K, Jackson D, Sanders D, Sunday A, Okegbe-Eze, Williams, Mshweshwe, Henge, Gomba, Nikodem, Khondowe, Mwiya M, Lusaka, Chizyuka, Phiri, Imakando, Musaku, Kapasa, Rutagwera D, Clement, Mwaba, Matoba, Mwaba, Siumita, Chola, Mwamutanda. Changes in body mass index and hemoglobin concentration in breastfeeding women living with HIV with a CD4 count over 350: Results from 4 African countries (The ANRS 12174 trial). PLoS ONE. 2017;12(5):e0177259eng
dc.description.abstractIntroduction: Breastfeeding is recommended for infants born to HIV-infected women in low-income settings. Both breastfeeding and HIV-infection are energy demanding. Our objective was to explore how exclusive and predominant breastfeeding changes body mass index (BMI) among breastfeeding HIV1-positive women participating in the ANRS12174 trial (clinical trial no NCT0064026). Methods: HIV-positive women (n = 1 267) with CD4 count >350, intending to breastfeed HIV-negative infants were enrolled from Burkina Faso, South Africa, Uganda and Zambia and counselled on breastfeeding. N = 1 216 were included in the analysis. The trial compared Lamivudine and Lopinavir/Ritonavir as a peri-exposure prophylaxis. We ran a linear mixed-effect model with BMI as the dependent variable and exclusive or predominant breastfeeding duration as the key explanatory variable. Results: Any breastfeeding or exclusive/predominant) breastfeeding was initiated by 99.6% and 98.6% of the mothers respectively in the first week after birth. The median (interquartile range: IQR) duration of the group that did any breastfeeding or the group that did exclusive /predominant breastfeeding were 9.5 (7.5; 10.6) and 5.8 (5.6; 5.9)) months, respectively. The median (IQR) age, BMI, CD4 count, and HIV viral load at baseline (day 7) were 27 (23.3; 31) years, 23.7 (21.3; 27.0) kg/m2, 530 (432.5; 668.5) cells/μl and 0.1 (0.8; 13.7)1000 copies/mL, respectively. No major change in mean BMI was seen in this cohort over a 50-week period during lactation. The mean change between 26 and 50 weeks after birth was 0.7 kg/m2. Baseline mean BMI (measured on day 7 postpartum) and CD4 count were positively associated with maternal BMI change, with a mean increase of 1.0 kg/m2 (0.9; 1.0) per each additional baseline-BMI kilogram and 0.3 kg/m2 (0.2; 0.5) for each additional CD4 cell/μl, respectively. Conclusion: Breastfeeding was not negatively correlated with the BMI of HIV-1 infected Sub-Saharan African mothers. However, a higher baseline BMI and a CD4 count >500 cells/μl were associated with maternal BMI during the exclusive/ predominant breastfeeding period. Considering the benefits of breast milk for the infants and the recurrent results from different studies that breastfeeding is not harmful to the HIV-1-infected mothers, this study also supports the WHO 2016 guidelines on infant feeding that mothers living with HIV should breastfeed where formula is not safe for at least 12 months and up to 24 months, given that the right treatment or prophylaxis for the infection is administered. These findings and conclusions cannot be extrapolated to women who are immune-compromised or have AIDS.en_US
dc.rightsAttribution CC BYeng
dc.titleChanges in body mass index and hemoglobin concentration in breastfeeding women living with HIV with a CD4 count over 350: Results from 4 African countries (The ANRS 12174 trial)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalPLoS ONE
dc.relation.projectNorges forskningsråd: 220887

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