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dc.contributor.authorHenjum, Sigrunen_US
dc.contributor.authorKvestad, Ingriden_US
dc.contributor.authorShrestha, Merinaen_US
dc.contributor.authorUlak, Manjesworien_US
dc.contributor.authorChandyo, Ram K.en_US
dc.contributor.authorThorne-Lyman, Andrew L.en_US
dc.contributor.authorShrestha, Prakash S.en_US
dc.contributor.authorKjellevold, Marianen_US
dc.contributor.authorHysing, Marien_US
dc.contributor.authorStrand, Tor A.en_US
dc.PublishedHenjum S, Kvestad I, Shrestha M, Ulak M, Chandyo RK, Thorne-Lyman AL, Shrestha PS, Kjellevold MK, Hysing M, Strand TA. Erythrocyte DHA and AA in infancy is not associated with general development five years later in Nepalese children. Nutrition Journal. (2018) 17:70eng
dc.description.abstractBackground Long chain polyunsaturated fatty acids (LCPUFA) especially docosahexaenoic acid (DHA) and arachidonic acid (AA) are crucial for normal brain development in utero and in early infancy. Data on fatty acid status and cognitive development in infants and children from low-income countries are scarce. Methods We examined the association between the DHA and AA status in infancy (n = 320) and developmental status and cognitive functioning five years later. At five years of age, we measured development by the Ages and Stages Questionnaire 3rd. ed. (ASQ-3) and cognitive functioning by subtests from the neuropsychological test battery NEPSY II. In addition, infant fatty acid composition in red blood cells (RBC) was analyzed. In multiple linear and logistic regression models, we estimated the associations between DHA and AA status in infancy and scores on the ASQ-3 and the NEPSY II subtests. Results There were no notable associations between infant AA and DHA status, and the scores on the ASQ-3 and the NEPSY II subtests five years later. It should be noted that we found better than expected concentrations of erythrocyte DHA and AA among the infants, and the ASQ scores were left-skewed, which limited the ability to identify associations. Conclusion DHA and AA status in infancy is seemingly not related to neurodevelopment measured 5 years later in this peri-urban population from Nepal.en_US
dc.rightsAttribution CC BYeng
dc.subjectPolyunsaturated fatty acidseng
dc.subjectPlasma phospholipidseng
dc.subjectDevelopmental statuseng
dc.subjectCognitive functioningeng
dc.subjectFollow up studyeng
dc.subjectNepalese childreneng
dc.titleErythrocyte DHA and AA in infancy is not associated with general development five years later in Nepalese childrenen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s). 2018
dc.source.journalNutrition Journal

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