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dc.contributor.authorKuiper, Ingrid Nordeideen_US
dc.contributor.authorSvanes, Cecilieen_US
dc.contributor.authorBenediktsdóttir, Bryndísen_US
dc.contributor.authorBertelsen, Randi Jacobsenen_US
dc.contributor.authorBråbäck, Lennarten_US
dc.contributor.authorDharmage, Shyamali C.en_US
dc.contributor.authorHolm, Mathiasen_US
dc.contributor.authorJanson, Christeren_US
dc.contributor.authorJõgi, Rainen_US
dc.contributor.authorMalinovschi, Andreien_US
dc.contributor.authorMatheson, Melanieen_US
dc.contributor.authorMoratalla, Jesús Martínezen_US
dc.contributor.authorGomez Real, Franciscoen_US
dc.contributor.authorSánchez-Ramos, José Luisen_US
dc.contributor.authorSchlünssen, Vivien_US
dc.contributor.authorTimm, Signeen_US
dc.contributor.authorJohannessen, Aneen_US
dc.PublishedKuiper IN, Svanes C, Benediktsdóttir B, Bertelsen R, Bråbäck L, Dharmage SC, Holm M, Janson C, Jõgi R, Malinovschi A, Matheson M, Moratalla, Gomez Real F, Sánchez-Ramos JL, Schlünssen V, Timm S, Johannessen A. Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study. BMC Pulmonary Medicine. 2018;18:122eng
dc.description.abstractBackground: Self-report questionnaires are commonly used in epidemiology, but may be susceptible to misclassification, especially if answers are given on behalf of others, e.g. children or parents. The aim was to determine agreement and analyse predictors of disagreement in parents’ reports of offspring asthma, and in offspring reports of parents’ asthma. Methods: In the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study, 6752 offspring (age range 18–51 years) and their parents (age range 39–66 years) reported their own and each other’s asthma status. Agreement between asthma reports from offspring and parents was determined by calculating sensitivity, specificity, positive and negative predictive value and Cohen’s kappa. The participants’ own answers regarding themselves were defined as the gold standard. To investigate predictors for disagreement logistic regression analyses were performed to obtain odds ratios (OR) with 95% confidence intervals (CI) for sex, smoking status, education, comorbidity and severity of asthma. Results: Agreement was good for parental report of offspring early onset asthma (< 10 years, Cohen’s kappa 0.72) and moderate for offspring later onset asthma (Cohen’s kappa 0.46). Specificity was 0.99 for both, and sensitivity was 0.68 and 0.36, respectively. For offspring report of maternal and paternal asthma the agreement was good (Cohen’s kappa 0.69 and 0.68), specificity was 0.96 and 0.97, and sensitivity was 0.72 and 0.68, respectively. The positive predictive value (PPV) was lowest for offspring report of maternal asthma (0.75), and highest for parents’ report of early onset asthma in the offspring (0.83). The negative predictive value (NPV) was high for all four groups (0.94–0.97). In multivariate analyses current smokers (OR = 1.46 [95% CI 1.05, 2.02]) and fathers (OR = 1.31 [95% CI 1.08, 1.59]) were more likely to report offspring asthma incorrectly. Offspring wheeze was associated with reporting parental asthma incorrectly (OR = 1.60 [95% CI 1.21, 2.11]), both under- and over reporting. Conclusions: Asthma reports across generations show moderate to good agreement, making information from other generations a useful tool in the absence of direct reports.en_US
dc.rightsAttribution CC BYeng
dc.titleAgreement in reporting of asthma by parents or offspring - the RHINESSA generation studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Authors
dc.source.journalBMC Pulmonary Medicine

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