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dc.contributor.authorWaruru, Anthony K.en_US
dc.date.accessioned2019-10-08T08:47:26Z
dc.date.issued2019-06-28
dc.date.submitted2019-06-14T09:51:43.742Z
dc.identifiercontainer/b3/b5/31/12/b3b53112-902f-4bb4-9c2f-7a66858e466a
dc.identifier.isbn9788230869864en_US
dc.identifier.isbn9788230859223en_US
dc.identifier.urihttps://hdl.handle.net/1956/20912
dc.descriptionPostponed access: the file will be accessible after 2020-06-28en_US
dc.description.abstractBackground: Kenya is a country in sub-Saharan Africa (SSA) with an HIV prevalence in the adult population is around 5%, which is considered to be a generalized HIV epidemic. The generalized nature of the epidemic makes it difficult to target HIV services and interventions due to misalignment of geographic planning units and finer locations that may need extra resources. This thesis explored geospatial features and their associations with the HIV epidemic with a view of identifying gaps in prevention, care, and treatment. Using a variety of spatial statistics and analytics and mapping, we point out geographic areas that need focussed and intensified HIV interventions. Methods: In Paper I, we conducted a spatial scan statistical analysis to identify hotspots with disproportionate HIV infections using cross-sectional household survey data. In Paper II, we identified disparate geographic regions with high numbers of newly diagnosed HIV infections using routine program data. In Paper III, we conducted spatial-temporal analyses to show impact of prevention of mother to child transmission of HIV (PMTCT) through reduced rates of HIV infections among infants. In Paper IV, we used spatial-temporal analyses and structural equation models to show the covariance relationship of antiretroviral therapy (ART) and viral load suppression (VLS) in reduced HIV positivity over time in Kenya. Results: In Paper I, we have shown that HIV infection in Kenya exhibits localized geographic clustering associated with socio-demographic and behavioural factors, suggesting disproportionate exposure to higher HIV-risk. Identification of these clusters reveals the right places for targeting priority-tailored HIV interventions. The newly diagnosed HIV positives in Kenya are not necessarily, where the HIV burden is high. In Paper II, we identified wide-ranging spatial variation of new HIV diagnoses through cluster and hotspot identification analyses. High HIV-burden sub-National units (SNUs)/counties contain most high yielding sites but some sites are also in low-burden SNUs. Targeting HIV testing services for sites in low-burden regions needs a Geospatial approach. An outcome measure of the success of the PMTCT program through reduction of transmission is highlighted in Paper III. During this period – before universal treatment – the PMTCT program in this region had not reached the target rate of ≤50 cases per 100,000 live births. Using spatial-temporal models with covariates provided better estimates of prevalence and explained the geographically distributed disease burden. In Paper IV we show that over a 3-years period, (2015-2017), improved viral load suppression rates had a direct effect on reduced HIV positivity rates during an era of scaled up ART coverage in Kenya. To assess the trends and impact of implementation of scaled-up care and treatment, spatial-temporal analyses help in identification of geographic areas that need focused interventions. Conclusions: HIV prevalence in Kenya, though generalized, ought to be looked at more critically. Some efforts at epidemic control including ending mother to child transmission (e-MTCT) have born fruits though with geographical disparities. Given the present density of low-yield HTS sites in Kenya, geographic coverage and access to HTS may need better targeting at the spatial level to achieve knowledge of status for at least 90% of the population. Access to HTS is needed everywhere in Kenya, yet, targeting is difficult in low prevalence areas. Gains in reduced number of new HIV diagnoses have been demonstrated where viral load suppression rates are good. This study has demonstrated that geospatial analyses and mapping makes it easier to define refined geographic areas and hotspots in need of enhanced HIV prevention and treatment interventions. We have provided evidence that there are geographic disparities in HIV program impact in Kenya. Micro location-based planning is necessary for improved resource allocation. We recommend clustering analyses to identify areas with disproportionately high number of HIV-infected persons for re-allocation of resources within SNUs and continued use of geospatial analyses for advocacy and planning to help in achieving HIV epidemic control in Kenya.en_US
dc.language.isoengeng
dc.publisherThe University of Bergeneng
dc.relation.haspartPaper I: Waruru A, Achia TNO, Tobias JL, Ng’ang’a J, Mwangi M, Wamicwe J, Zielinski- Gutierrez E, Oluoch T, Muthama E, Tylleskär T. Finding Hidden HIV Clusters to Support Geographic-Oriented HIV Interventions in Kenya. J Acquir Immune Defic Syndr 2018, 78:144–154. The article is not available in BORA due to publisher restrictions. The published version is available at: <a href="https://doi.org/10.1097/qai.0000000000001652" target="blank">https://doi.org/10.1097/qai.0000000000001652</a>en_US
dc.relation.haspartPaper II: Anthony Waruru, Joyce Wamicwe, Jonathan Mwangi, Thomas N. O. Achia, Emily Zielinski-Gutierrez, Lucy Ng’ang’a, Fredrick Miruka, Peter Yegon, Davies Kimanga, James L. Tobias, Peter W. Young, Kevin M. De Cock, Thorkild Tylleskär. Where are the newly diagnosed HIV-infected persons in Kenya? Time to consider finer scale geospatially guided targeting to reach the “first 90”. The article is not available in BORA.en_US
dc.relation.haspartPaper III: Waruru A, Achia TNO, Muttai H, Ng’ang’a L, Zielinski-Gutierrez E, Ochanda B, Katana A, Young PW, Tobias JL, Juma P, De Cock KM, Tylleskär T. Spatial–temporal trend for mother-to-child transmission of HIV up to infancy and during pre-Option B+ in western Kenya, 2007–13. PeerJ 2018;6:e4427. The article is available in the main thesis. The article is also available at: <a href="https://doi.org/10.7717/peerj.4427" target="blank">https://doi.org/10.7717/peerj.4427</a>en_US
dc.relation.haspartPaper IV: Anthony Waruru, Joyce Wamicwe, Maureen Kimani, Lucy Ng’ang’a, Kenneth Masamaro, Salome Okutoyi, Thomas N. O. Achia, Jacques Muthusi Kimeu, Emily Zielinski-Gutierrez, James L. Tobias, Stella Njuguna, Catherine Mbaire, Kevin M. De Cock, Thorkild Tylleskär. ART coverage and viral load suppression rates as correlates to new HIV diagnoses, in Kenya; Spatial-temporal analyses 2015-17. The article is not available in BORA.en_US
dc.rightsAttribution-NonCommercial-NoDerivs (CC BY-NC-ND)eng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.titleMapping HIV in Kenya: Geospatial variability of HIV diagnoses, treatment, and impact : Implications for HIV epidemic controlen_US
dc.typeDoctoral thesis
dc.date.updated2019-06-14T09:51:43.742Z
dc.rights.holderCopyright the Author.
dc.contributor.orcidhttps://orcid.org/0000-0002-4281-6345
dc.identifier.cristin1707837
fs.unitcode13-26-0
dc.date.embargoenddate2020-06-28


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